Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: Case study Journal Article
| Authors: | Allen, J. C.; Judkins, A. R.; Rosenblum, M. K.; Biegel, J. A. |
| Article Title: | Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: Case study |
| Abstract: | We report an atypical teratoid/rhabdoid tumor arising in a ganglioglioma from an 11-year-old male who had been treated over a nine-year period. A combined histologic, immunohistochemical, and molecular genetic analysis confirmed this diagnosis. Molecular genetic studies demonstrated a mutation in exon 9 of the INI1 gene in the tumor, which was not present in the patient's blood. This report is the first to describe progression of a ganglioglioma to atypical teratoid/rhabdoid tumor. Copyright © 2006 by the Society for Neuro-Oncology. |
| Keywords: | immunohistochemistry; cancer chemotherapy; child; human tissue; school child; gene mutation; human cell; exon; frameshift mutation; dna-binding proteins; disease course; histopathology; case report; temozolomide; molecular genetics; nuclear magnetic resonance imaging; glioma; brain neoplasms; genetic analysis; chromosomal proteins, non-histone; carboplatin; etoposide; vincristine; tumor biopsy; lomustine; procarbazine; transcription factors; death; amino acid sequence; conservative treatment; base sequence; teratoma; dna mutational analysis; fatal outcome; chromosome protein; astrocytoma; neoplasms, multiple primary; tioguanine; rhabdoid tumor; chromosomes, human, pair 22; ganglioglioma; visual system; hsnf5/ini1; atypical teratoid tumor |
| Journal Title: | Neuro-Oncology |
| Volume: | 8 |
| Issue: | 1 |
| ISSN: | 1522-8517 |
| Publisher: | Oxford University Press |
| Date Published: | 2006-01-01 |
| Start Page: | 79 |
| End Page: | 82 |
| Language: | English |
| DOI: | 10.1215/s1522851705000347 |
| PUBMED: | 16443951 |
| PROVIDER: | scopus |
| PMCID: | PMC1871926 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 4 June 2012" - "CODEN: NEURJ" - "Source: Scopus" |
