Porokeratosis of Mibelli following bone marrow transplantation Journal Article
| Authors: | Alexis, A. F.; Busam, K.; Myskowski, P. L. |
| Article Title: | Porokeratosis of Mibelli following bone marrow transplantation |
| Abstract: | Background: Porokeratosis is a rare disorder of keratinization with both autosomal dominant and acquired forms. Immunosuppression has been associated with the development of porokeratosis in numerous case reports and series. To our knowledge, however, only five cases of porokeratosis have been reported following bone marrow transplantation. Result: We report five cases of porokeratosis of Mibelli following bone marrow transplantation. The diagnosis of porokeratosis was made between 1 and 13 years post-transplantation. The underlying malignancy in four of the five cases was leukemia, while the fifth patient had non-Hodgkin's lymphoma. Porokeratosis developed during remission in the four leukemia patients, whereas, in the fifth patient, it occurred during a relapse of lymphoma. Conclusions: Porokeratosis may develop following bone marrow transplantation. Our five cases double the number reported in the medical literature, and the incidence of porokeratosis following bone marrow transplantation may be significantly higher than previously recognized. As cutaneous carcinomas have been reported in association with porokeratosis, careful surveillance for porokeratosis in bone marrow transplant recipients is warranted. © 2004 The International Society of Dermatology. |
| Keywords: | adult; cancer chemotherapy; clinical article; controlled study; human tissue; middle aged; leukemia; human cell; busulfan; fludarabine; hydroxyurea; prednisone; disease course; histopathology; anamnesis; cancer localization; cancer combination chemotherapy; cancer radiotherapy; rituximab; disease association; skin biopsy; incidence; skin cancer; health survey; cyclophosphamide; vincristine; chronic myeloid leukemia; thiotepa; monoclonal antibody; cancer regression; nonhodgkin lymphoma; whole body radiation; lymphoma, non-hodgkin; cancer size; graft versus host reaction; cancer relapse; medical literature; immunosuppressive treatment; bone marrow transplantation; drug dose regimen; cyclosporin; lymphocytoma; immunosuppression; porokeratosis; porokeratosis mibelli |
| Journal Title: | International Journal of Dermatology |
| Volume: | 45 |
| Issue: | 4 |
| ISSN: | 0011-9059 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2006-04-01 |
| Start Page: | 361 |
| End Page: | 365 |
| Language: | English |
| DOI: | 10.1111/j.1365-4632.2006.02509.x |
| PUBMED: | 16650158 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 12" - "Export Date: 4 June 2012" - "CODEN: IJDEB" - "Source: Scopus" |
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