Definitive treatment of metastatic nasopharyngeal carcinoma: Report of 5 cases with review of literature Journal Article
| Authors: | Setton, J.; Wolden, S.; Caria, N.; Lee, N. |
| Article Title: | Definitive treatment of metastatic nasopharyngeal carcinoma: Report of 5 cases with review of literature |
| Abstract: | Background To review the treatment outcomes of patients presenting to Memorial Sloan-Kettering Cancer Center with metastatic nasopharyngeal carcinoma. Methods From April 1999 to April 2008, 5 patients with histologically confirmed nasopharyngeal carcinoma initially presenting with distant metastasis underwent chemotherapy and definitive radiation therapy at our institution. Each patient received platinum-based chemotherapy concurrently with definitive radiotherapy to the primary region and subsequent consolidation radiotherapy to distant metastases. In addition, 2 patients received induction chemotherapy (cisplatin, fluorouracil), and 3 others received adjuvant chemotherapy (cisplatin or carboplatin, fluorouracil). Results Of 5 patients initially presenting to our institution with M1 disease, 2 have no evidence of disease as of their last follow-up (29 and 91 months). The remaining 3 patients had progression of disease within 12 months of the start of treatment. Conclusions Long-term disease-free survival is possible in a select group of patients with M1 disease at presentation treated with platinum-based chemotherapy and definitive radiotherapy © 2010 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer chemotherapy; clinical article; middle aged; cancer surgery; primary tumor; young adult; fatigue; review; intensity modulated radiation therapy; cisplatin; fluorouracil; antineoplastic agents; bone metastasis; chemotherapy, adjuvant; drug megadose; nuclear magnetic resonance imaging; carboplatin; computer assisted tomography; bleeding; mucosa inflammation; peripheral neuropathy; palliative therapy; docetaxel; alkaline phosphatase; dysphagia; disease severity; imrt; drug response; hypermetabolism; carcinoma; neoplasm metastasis; xerostomia; nausea and vomiting; nasopharynx carcinoma; dermatitis; headache; nasopharyngeal carcinoma; nasopharyngeal neoplasms; lymphadenopathy; chemoradiotherapy; metastatic; whole body pet; head-and-neck cancer; transsphenoidal surgery; npc; consolidation chemotherapy; ethmoidectomy; metastatic nasopharyngeal carcinoma |
| Journal Title: | Head & Neck |
| Volume: | 34 |
| Issue: | 5 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2012-05-01 |
| Start Page: | 753 |
| End Page: | 757 |
| Language: | English |
| DOI: | 10.1002/hed.21608 |
| PROVIDER: | scopus |
| PUBMED: | 22488786 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2012" - "CODEN: HEANE" - "Source: Scopus" |
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