Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: An update of the Memorial Sloan-Kettering Cancer Center experience Journal Article


Authors: Setton, J.; Caria, N.; Romanyshyn, J.; Koutcher, L.; Wolden, S. L.; Zelefsky, M. J.; Rowan, N.; Sherman, E. J.; Fury, M. G.; Pfister, D. G.; Wong, R. J.; Shah, J. P.; Kraus, D. H.; Shi, W.; Zhang, Z.; Schupak, K. D.; Gelblum, D. Y.; Rao, S. D.; Lee, N. Y.
Article Title: Intensity-modulated radiotherapy in the treatment of oropharyngeal cancer: An update of the Memorial Sloan-Kettering Cancer Center experience
Abstract: Purpose: To update the Memorial Sloan-Kettering Cancer Center's experience with intensity-modulated radiotherapy (IMRT) in the treatment of oropharyngeal cancer (OPC). Methods and Materials: Between September 1998 and April 2009, 442 patients with histologically confirmed OPC underwent IMRT at our center. There were 379 men and 63 women with a median age of 57 years (range, 27-91). The disease was Stage I in 2%, Stage II in 4%, Stage III in 21%, and Stage IV in 73% of patients. The primary tumor subsite was tonsil in 50%, base of tongue in 46%, pharyngeal wall in 3%, and soft palate in 2%. The median prescription dose to the planning target volume of the gross tumor was 70 Gy for definitive (n = 412) cases and 66 Gy for postoperative cases (n = 30). A total 404 patients (91%) received chemotherapy, including 389 (88%) who received concurrent chemotherapy, the majority of which was platinum-based. Results: Median follow-up among surviving patients was 36.8 months (range, 3-135). The 3-year cumulative incidence of local failure, regional failure, and distant metastasis was 5.4%, 5.6%, and 12.5%, respectively. The 3-year OS rate was 84.9%. The incidence of late dysphagia and late xerostomia ≥Grade 2 was 11% and 29%, respectively. Conclusions: Our results confirm the feasibility of IMRT in achieving excellent locoregional control and low rates of xerostomia. According to our knowledge, this study is the largest report of patients treated with IMRT for OPC. Copyright © 2012 Elsevier Inc. Printed in the USA. All rights reserved.
Keywords: dysphagia; imrt; xerostomia; head-and-neck cancer; oropharyngeal cancer
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 82
Issue: 1
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 2012-01-01
Start Page: 291
End Page: 298
Language: English
DOI: 10.1016/j.ijrobp.2010.10.041
PROVIDER: scopus
PUBMED: 21167652
DOI/URL:
Notes: --- - "Export Date: 1 February 2012" - "CODEN: IOBPD" - "Source: Scopus"
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MSK Authors
  1. Zhigang Zhang
    240 Zhang
  2. Michael J Zelefsky
    615 Zelefsky
  3. Weiji Shi
    111 Shi
  4. Dennis Kraus
    258 Kraus
  5. Daphna Y Gelblum
    78 Gelblum
  6. Suzanne L Wolden
    419 Wolden
  7. Eric J Sherman
    149 Sherman
  8. Nancy Y. Lee
    547 Lee
  9. Nicola Caria
    12 Caria
  10. David G Pfister
    247 Pfister
  11. Matthew G Fury
    93 Fury
  12. Richard J Wong
    228 Wong
  13. Shyam S Rao
    81 Rao
  14. Karen D Schupak
    67 Schupak
  15. Jatin P Shah
    538 Shah
  16. Jeremy Setton
    65 Setton
  17. Nicholas Ray Rowan
    2 Rowan