Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma Journal Article
| Authors: | Nishikawa, H.; Maeda, Y.; Ishida, T.; Gnjatic, S.; Sato, E.; Mori, F.; Sugiyama, D.; Ito, A.; Fukumori, Y.; Utsunomiya, A.; Inagaki, H.; Old, L. J.; Ueda, R.; Sakaguchi, S. |
| Article Title: | Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma |
| Abstract: | Adult T-cell leukemia/lymphoma (ATLL) is an intractable hematologic malignancy caused by human T-lymphotropic virus type 1 (HTLV-1), which infects approximately 20 million people worldwide. Here, we have explored the possible expression of cancer/testis (CT) antigens by ATLL cells, as CT antigens are widely recognized as ideal targets of cancer immunotherapy against solid tumors. A high percentage (87.7%) of ATLL cases (n = 57) expressed CT antigens at the mRNA level: NY-ESO-1 (61.4%), MAGE-A3 (31.6%), and MAGE-A4 (61.4%). CT antigen expression was confirmed by immunohistochemistry. This contrasts with other types of lymphoma or leukemia, which scarcely express these CT antigens. Humoral immune responses, particularly against NY-ESO-1, were detected in 11.6% (5 of 43) and NY-ESO-1-specific CD8 + T-cell responses were observed in 55.6% (5 of 9) of ATLL patients. NY-ESO-1-specific CD8 +T cells recognized autologous ATLL cells and produced effector cytokines. Thus, ATLL cells characteristically express CT antigens and therefore vaccination with CT antigens can be an effective immunotherapy of ATLL. © 2012 by The American Society of Hematology. |
| Keywords: | immunohistochemistry; adult; middle aged; drug targeting; antigen expression; cd8+ t lymphocyte; cancer immunotherapy; reverse transcription polymerase chain reaction; neoplasm proteins; cell line; membrane proteins; in vitro study; tumor antigen; gene expression regulation, neoplastic; cellular immunity; immunotherapy; antigens; antigens, neoplasm; blood sampling; cancer testis antigen; melanoma antigen 3; ny eso 1 antigen; antigen detection; cancer immunization; lymphoma; autoantigen; cytokine production; humoral immunity; t cell leukemia; testis; leukemia-lymphoma, adult t-cell; gene expression regulation, leukemic; melanoma antigen 4; immunity, humoral; molecular targeted therapy |
| Journal Title: | Blood |
| Volume: | 119 |
| Issue: | 13 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2012-03-29 |
| Start Page: | 3097 |
| End Page: | 3104 |
| Language: | English |
| DOI: | 10.1182/blood-2011-09-379982 |
| PROVIDER: | scopus |
| PUBMED: | 22323448 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2012" - "CODEN: BLOOA" - "Source: Scopus" |
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