Interleukin-22 drives endogenous thymic regeneration in mice Journal Article
| Authors: | Dudakov, J. A.; Hanash, A. M.; Jenq, R. R.; Young, L. F.; Ghosh, A.; Singer, N. V.; West, M. L.; Smith, O. M.; Holland, A. M.; Tsai, J. J.; Boyd, R. L.; van den Brink, M. R. M. |
| Article Title: | Interleukin-22 drives endogenous thymic regeneration in mice |
| Abstract: | Endogenous thymic regeneration is a crucial function that allows for renewal of immune competence after stress, infection, or immunodepletion. However, the mechanisms governing this regeneration remain poorly understood. We detail such a mechanism, centered on interleukin-22 (IL-22) and triggered by the depletion of CD4 +CD8 + double-positive thymocytes. Intrathymic levels of IL-22 were increased after thymic insult, and thymic recovery was impaired in IL-22-deficient mice. IL-22, which signaled through thymic epithelial cells and promoted their proliferation and survival, was up-regulated by radio-resistant RORĪ³(t) +CCR6 +NKp46 -lymphoid tissue inducer cells after thymic injury in an IL-23-dependent manner. Administration of IL-22 enhanced thymic recovery after total body irradiation. These studies reveal mechanisms of endogenous thymic repair and offer innovative regenerative strategies for improving immune competence. |
| Keywords: | signal transduction; survival; genetics; nonhuman; radiation dose; cd8+ t lymphocyte; cell proliferation; mouse; animal; cytology; metabolism; animals; mice; cell survival; mus; dendritic cell; mice, inbred balb c; mice, inbred c57bl; radiation exposure; physiology; radiation dosage; c57bl mouse; regeneration; immunology; dendritic cells; whole body radiation; immune response; bagg albino mouse; thymus; thymus gland; cell damage; cd4+ t lymphocyte; recombinant proteins; recombinant protein; epithelium cell; epithelial cells; cell count; upregulation; rodent; cell regeneration; up-regulation; t cell depletion; lymphoid tissue; lymphocyte; lymphocytes; thymocyte; interleukin 22; interleukin derivative; interleukin-22; interleukins; whole-body irradiation; interleukin 23; retinoid related orphan receptor gamma; interleukin receptor; thymocytes; interleukin 22 receptor; interleukin-22 receptor; rorc protein, mouse; interleukin-23; nuclear receptor subfamily 1, group f, member 3; receptors, interleukin; infectivity; irradiance |
| Journal Title: | Science |
| Volume: | 335 |
| Issue: | 6077 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2012-04-06 |
| Start Page: | 91 |
| End Page: | 95 |
| Language: | English |
| DOI: | 10.1126/science.1218004 |
| PROVIDER: | scopus |
| PUBMED: | 22383805 |
| PMCID: | PMC3616391 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2012" - "CODEN: SCIEA" - "Source: Scopus" |
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