Oncolytic Newcastle disease virus for cancer therapy: Old challenges and new directions Journal Article
| Authors: | Zamarin, D.; Palese, P. |
| Article Title: | Oncolytic Newcastle disease virus for cancer therapy: Old challenges and new directions |
| Abstract: | Newcastle disease virus (NDV) is an avian paramyxovirus, which has been demonstrated to possess significant oncolytic activity against mammalian cancers. This review summarizes the research leading to the elucidation of the mechanisms of NDV-mediated oncolysis, as well as the development of novel oncolytic agents through the use of genetic engineering. Clinical trials utilizing NDV strains and NDV-based autologous tumor cell vaccines will expand our knowledge of these novel anticancer strategies and will ultimately result in the successful use of the virus in the clinical setting. |
| Keywords: | interferon; apoptosis; protein; immunotherapy; colorectal-cancer; apoptosis-inducing ligand; malignant-melanoma; ndv; oncolytic; ii; active specific; hemagglutinin-neuraminidase protein; tumor-cell vaccine; ehrlich ascites tumor; bispecific fusion; selective gene-transfer; avian influenza-virus |
| Journal Title: | Future Microbiology |
| Volume: | 7 |
| Issue: | 3 |
| ISSN: | 1746-0913 |
| Publisher: | Future Medicine |
| Date Published: | 2012-03-01 |
| Start Page: | 347 |
| End Page: | 367 |
| Language: | English |
| ACCESSION: | WOS:000301168900009 |
| DOI: | 10.2217/fmb.12.4 |
| PROVIDER: | wos |
| PUBMED: | 22393889 |
| PMCID: | PMC4241685 |
| Notes: | --- - Review - "Source: Wos" |
