Immunologic correlates of the abscopal effect in a patient with melanoma Journal Article


Authors: Postow, M. A.; Callahan, M. K.; Barker, C. A.; Yamada, Y.; Yuan, J.; Kitano, S.; Mu, Z.; Rasalan, T.; Adamow, M.; Ritter, E.; Sedrak, C.; Jungbluth, A. A.; Chua, R.; Yang, A. S. ; Roman, R. A.; Rosner, S.; Benson, B.; Allison, J. P.; Lesokhin, A. M.; Gnjatic, S.; Wolchok, J. D.
Article Title: Immunologic correlates of the abscopal effect in a patient with melanoma
Abstract: The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.) Copyright © 2012 Massachusetts Medical Society.
Journal Title: New England Journal of Medicine
Volume: 366
Issue: 10
ISSN: 0028-4793
Publisher: Massachusetts Medical Society  
Date Published: 2012-03-08
Start Page: 925
End Page: 931
Language: English
DOI: 10.1056/NEJMoa1112824
PROVIDER: scopus
PUBMED: 22397654
PMCID: PMC3345206
DOI/URL:
Notes: --- - "Export Date: 2 April 2012" - "CODEN: NEJMA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Jedd D Wolchok
    669 Wolchok
  2. Yoshiya Yamada
    359 Yamada
  3. Michael Andrew Postow
    187 Postow
  4. Christopher Barker
    116 Barker
  5. Margaret Kathleen Callahan
    103 Callahan
  6. Ruth-Ann Roman
    30 Roman
  7. James P Allison
    129 Allison
  8. Sacha Gnjatic
    111 Gnjatic
  9. Achim Jungbluth
    341 Jungbluth
  10. Erika Ritter
    34 Ritter
  11. Jianda Yuan
    100 Yuan
  12. Shigehisa Kitano
    10 Kitano
  13. Ramon Chua
    19 Chua
  14. Alexander Meyer Lesokhin
    118 Lesokhin
  15. Teresa Rasalan
    25 Rasalan
  16. Matthew J Adamow
    10 Adamow
  17. Zhenyu Mu
    10 Mu
  18. Christine Sedrak
    4 Sedrak