Synapse - Immunologic correlates of the abscopal effect in a patient with melanoma

Immunologic correlates of the abscopal effect in a patient with melanoma Journal Article

Authors:	Postow, M. A.; Callahan, M. K.; Barker, C. A.; Yamada, Y.; Yuan, J.; Kitano, S.; Mu, Z.; Rasalan, T.; Adamow, M.; Ritter, E.; Sedrak, C.; Jungbluth, A. A.; Chua, R.; Yang, A. S. ; Roman, R. A.; Rosner, S.; Benson, B.; Allison, J. P.; Lesokhin, A. M.; Gnjatic, S.; Wolchok, J. D.
Article Title:	Immunologic correlates of the abscopal effect in a patient with melanoma
Abstract:	The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.) Copyright © 2012 Massachusetts Medical Society.
Journal Title:	New England Journal of Medicine
Volume:	366
Issue:	10
ISSN:	0028-4793
Publisher:	Massachusetts Medical Society
Date Published:	2012-03-08
Start Page:	925
End Page:	931
Language:	English
DOI:	10.1056/NEJMoa1112824
PROVIDER:	scopus
PUBMED:	22397654
PMCID:	PMC3345206
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84857815877&partnerID=40&md5=4138ee6c03c65acdb584ef40792c1b0a
Notes:	--- - "Export Date: 2 April 2012" - "CODEN: NEJMA" - "Source: Scopus"