The microcosmos of cancer Journal Article


Authors: Lujambio, A.; Lowe, S. W.
Article Title: The microcosmos of cancer
Abstract: The discovery of microRNAs (miRNAs) almost two decades ago established a new paradigm of gene regulation. During the past ten years these tiny non-coding RNAs have been linked to virtually all known physiological and pathological processes, including cancer. In the same way as certain key protein-coding genes, miRNAs can be deregulated in cancer, in which they can function as a group to mark differentiation states or individually as bona fide oncogenes or tumour suppressors. Importantly, miRNA biology can be harnessed experimentally to investigate cancer phenotypes or used therapeutically as a target for drugs or as the drug itself. © 2012 Macmillan Publishers Limited. All rights reserved.
Keywords: cancer chemotherapy; unclassified drug; acute granulocytic leukemia; review; cancer growth; liver cell carcinoma; nonhuman; pancreas cancer; antineoplastic agent; genetic analysis; neoplasm; cell proliferation; phenotype; protein bcl 2; melanoma; metastasis; apoptosis; ovary cancer; breast cancer; microrna; gene expression; protein; lung cancer; rna interference; tumor biopsy; in vivo study; pathology; bladder cancer; phosphatidylinositol 3 kinase; protein p53; dna methylation; prostate cancer; oncogene; genetic engineering; neuroblastoma; colon cancer; glioblastoma; cancer cell; lymphoma; cell migration; stomach cancer; down regulation; microenvironment; virus replication; cancer classification; kidney cancer; tumor; hepatitis c virus; chronic lymphatic leukemia; tumor gene; genetic code; short hairpin rna; oncogene myc; disease treatment; biogenesis; microrna 29; microrna let 7; drug; hypophysis adenoma; histone acetylation; microrna 155; microrna 15a; microrna 16 1; microrna 17 92; microrna 21; microrna 34; chronic hepatitis
Journal Title: Nature
Volume: 482
Issue: 7385
ISSN: 0028-0836
Publisher: Nature Publishing Group  
Date Published: 2012-02-15
Start Page: 347
End Page: 355
Language: English
DOI: 10.1038/nature10888
PROVIDER: scopus
PUBMED: 22337054
PMCID: PMC3509753
DOI/URL:
Notes: --- - "Export Date: 2 April 2012" - "CODEN: NATUA" - "Source: Scopus"
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  1. Scott W Lowe
    145 Lowe