Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia Journal Article
| Authors: | Klimek, V. M.; Dolezal, E. K.; Smith, L.; Soff, G.; Nimer, S. D. |
| Article Title: | Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia |
| Abstract: | Sodium salicylate is an inexpensive, readily available anti-inflammatory agent which inhibits NF-κB in in vitro models. We examined whether it was possible to safely achieve and maintain salicylate levels known to inhibit NF-κB in vitro in 11 patients with MDS or AML taking sodium salicylate. Most patients achieved the target blood salicylate level (20-30. mg/dL) with acceptable toxicity, including reversible grade 1/2 elevations of hepatic transaminases (. n=. 4) and ototoxicity (. n=. 4). One patient had grade 3/4 elevations in AST/ALT. This study suggests that sodium salicylate may be safely combined with conventional chemotherapy regimens which are not associated with significant ototoxicity or hepatotoxicity. © 2011 Elsevier Ltd. |
| Keywords: | adult; cancer chemotherapy; clinical article; controlled study; aged; aged, 80 and over; middle aged; acute granulocytic leukemia; leukemia, myeloid, acute; drug tolerability; neutropenia; dose response; drug dose reduction; drug efficacy; drug safety; drug withdrawal; side effect; outcome assessment; steady state; thrombocytopenia; tinnitus; immunoglobulin enhancer binding protein; in vitro study; drug effect; liver; myelodysplastic syndrome; anti-inflammatory agents, non-steroidal; nf-kappa b; thrombocyte count; clinical effectiveness; drug blood level; phase 1 clinical trial; hearing loss; myelodysplastic syndromes; ototoxicity; acute myelogenous leukemia; thrombocyte aggregation; platelet aggregation; sodium salicylate; nf-?b; salicylate sodium; balance impairment |
| Journal Title: | Leukemia Research |
| Volume: | 36 |
| Issue: | 5 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2012-05-01 |
| Start Page: | 570 |
| End Page: | 574 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2011.10.023 |
| PROVIDER: | scopus |
| PUBMED: | 22154022 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: LERED" - "Source: Scopus" |
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