Life in the fast lane: Mammalian disease models in the genomics era Journal Article
| Authors: | Dow, L. E.; Lowe, S. W. |
| Article Title: | Life in the fast lane: Mammalian disease models in the genomics era |
| Abstract: | Analyses of the human genome have proven extremely successful in identifying changes that contribute to human disease. Genetically engineered mice provide a powerful tool to analyze these changes, although they are slow and costly and do not always recapitulate human biology. Recent advances in genomic technologies, rodent-modeling approaches, and the production of patient-derived reprogrammed cell lines now provide a plethora of complementary systems to study disease states and test new therapies. Continued evolution and integration of these model systems will be the key to realizing the benefits of the genomic revolution and refining our understanding and treatment of human diseases. © 2012 Elsevier Inc. |
| Keywords: | disease course; review; nonhuman; mammalia; animals; mice; mice, knockout; mus; cell line; genetic association; rna interference; transgenic animal; mice, transgenic; disease model; mammal; genomics; genome; rats; rodentia; disease models, animal; induced pluripotent stem cells |
| Journal Title: | Cell |
| Volume: | 148 |
| Issue: | 6 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2012-03-16 |
| Start Page: | 1099 |
| End Page: | 1109 |
| Language: | English |
| DOI: | 10.1016/j.cell.2012.02.023 |
| PROVIDER: | scopus |
| PUBMED: | 22424222 |
| PMCID: | PMC3410373 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: CELLB" - "Source: Scopus" |
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