Quantitative modeling of Cerenkov light production efficiency from medical radionuclides Journal Article
| Authors: | Beattie, B. J.; Thorek, D. L. J.; Schmidtlein, C. R.; Pentlow, K. S.; Humm, J. L.; Hielscher, A. H. |
| Article Title: | Quantitative modeling of Cerenkov light production efficiency from medical radionuclides |
| Abstract: | There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choice of radionuclides. To generate this information we developed models of CR production efficiency based on the Frank-Tamm equation and models of CR distribution based on Monte-Carlo simulations of photon and β particle transport. All models were validated against direct measurements using multiple radionuclides and then applied to a number of radionuclides commonly used in biomedical applications. We show that two radionuclides, Ac-225 and In-111, which have been reported to produce CR in water, do not in fact produce CR directly. We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use. © 2012 Beattie et al. |
| Keywords: | controlled study; validation process; sensitivity analysis; radiation; imaging system; luminescence; medical technology; water; indium 111; photon; monte carlo method; electron; mathematical analysis; actinium 225; cerenkov radiation; frank tamm equation |
| Journal Title: | PLoS ONE |
| Volume: | 7 |
| Issue: | 2 |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Date Published: | 2012-01-01 |
| Start Page: | e31402 |
| Language: | English |
| DOI: | 10.1371/journal.pone.0031402 |
| PROVIDER: | scopus |
| PMCID: | PMC3282695 |
| PUBMED: | 22363636 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "Source: Scopus" |
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107Schmidtlein -
433Humm -
70Pentlow -
131Beattie
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