Liver resection for metastatic colorectal cancer in patients with concurrent extrahepatic disease: Results in 127 patients treated at a single center Journal Article

  

Authors:	Carpizo, D. R.; Are, C.; Jarnagin, W.; DeMatteo, R.; Fong, Y.; Gonen, M.; Blumgart, L.; D'Angelica, M.
Article Title:	Liver resection for metastatic colorectal cancer in patients with concurrent extrahepatic disease: Results in 127 patients treated at a single center
Abstract:	Background: Surgical resection for patients with hepatic and extrahepatic (EHD) colorectal metastases is controversial. We analyzed our experience with hepatic resection in patients with concomitant EHD. The aims were to characterize survival, recurrence rates, and factors associated with outcome. Methods: From 1992 to 2007, 1,369 patients underwent resection of hepatic colorectal metastases, of whom 127 (9%) had concurrent resection of EHD. Survival and recurrence were compared between patients with and without EHD. Survival data were stratified by site of metastatic involvement. Variables potentially associated with survival were analyzed in univariate and multivariate analyses. Results: Median follow-up was 24 months (range 3-152 months). The 3- and 5-year survival for patients with concomitant EHD were 47% and 26%, respectively, compared with 67% and 49%, for those without EHD (P < 0.001). Among the patients with EHD, multivariate analysis identified higher clinical risk score, incomplete resection of all EHD, EHD detected intraoperatively, and having received neoadjuvant chemotherapy to be independently associated with a worse survival. Patients with portal lymph node metastases had worse survival than those with lung or ovarian metastases. Among patients who had a complete resection of all disease, 95% recurred. Conclusion: Concurrent resection of hepatic and EHD in well-selected patients is associated with a possibility of long-term survival. The presence of limited and resectable EHD should not be an absolute contraindication to resection. The site of EHD and the nearly universal recurrence rate must be taken into consideration. © 2009 Society of Surgical Oncology.
Keywords:	cancer survival; controlled study; treatment outcome; survival rate; retrospective studies; major clinical study; cancer localization; cancer recurrence; cancer risk; liver neoplasms; outcome assessment; follow up; lymph node metastasis; lymphatic metastasis; neoplasm staging; prospective studies; colorectal cancer; neoplasm recurrence, local; peritoneal neoplasms; lung neoplasms; colorectal neoplasms; liver metastasis; lung metastasis; intraoperative period; adjuvant chemotherapy; liver resection; liver disease; hepatectomy; ovary metastasis; neoplasm invasiveness
Journal Title:	Annals of Surgical Oncology
Volume:	16
Issue:	8
ISSN:	1068-9265
Publisher:	Springer
Date Published:	2009-08-01
Start Page:	2138
End Page:	2146
Language:	English
DOI:	10.1245/s10434-009-0521-6
PUBMED:	19495884
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-67651001957&partnerID=40&md5=33a8cc571397831b3d47550f92ffccc5
Notes:	--- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: ASONF" - "Source: Scopus"

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