Hepatic artery infusional chemotherapy in patients with unresectable colorectal liver metastases and extrahepatic disease Journal Article

  


Authors: Ammori, J. B.; D'Angelica, M. I.; Fong, Y.; Cercek, A.; DeMatteo, R. P.; Allen, P. J.; Kingham, T. P.; Paty, P. B.; Jarnagin, W. R.; Kemeny, N. E.
Article Title: Hepatic artery infusional chemotherapy in patients with unresectable colorectal liver metastases and extrahepatic disease
Abstract: Background and Objectives Hepatic arterial infusional (HAI) chemotherapy combined with systemic chemotherapy is effective palliative therapy for unresectable colorectal cancer liver metastases (CRLM). Some patients considered for HAI have evidence of minimal extrahepatic disease (EHD), and the role of HAI in these situations is unknown. Methods All patients with unresectable CRLM treated with HAI and systemic chemotherapy from 2000 to 2009 were included. Survival of patients who were ultimately proven to have low-volume EHD was compared to those without EHD. Results Three hundred seventy-three patients were included in this study. Seventy-nine percent of patients were previously treated with chemotherapy. One hundred forty-five patients (39%) ultimately proved to have EHD. Median overall survival from HAI pump placement in patients without EHD was 32 months compared to 16 months for patients with EHD, P < 0.001. Median overall survival from HAI pump placement in patients with a single site of EHD was 18 months compared to 9 months for those with multiple sites of EHD, P = 0.01. Conclusions In this study of heavily pre-treated patients, overall survival was favorable in patients who proved to have EHD at one site. Copyright © 2012 Wiley Periodicals, Inc.
Keywords: adult; cancer chemotherapy; cancer survival; treatment outcome; aged; aged, 80 and over; middle aged; survival analysis; young adult; major clinical study; overall survival; liver neoplasms; positron emission tomography; follow-up studies; antineoplastic agent; prospective studies; colorectal cancer; computer assisted tomography; antineoplastic combined chemotherapy protocols; medical record review; retrospective study; colorectal neoplasms; liver metastasis; infusions, intra-arterial; regional chemotherapy; hepatic artery; colorectal liver metastases; extrahepatic disease; hepatic artery infusional chemotherapy; colorectal liver metastasis; bile duct disease
Journal Title: Journal of Surgical Oncology
Volume: 106
Issue: 8
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2012-12-01
Start Page: 953
End Page: 958
Language: English
DOI: 10.1002/jso.23204
PROVIDER: scopus
PUBMED: 22753355
DOI/URL:

http://release-www.scopus.com/inward/record.url?eid=2-s2.0-84869491604&partnerID=40&md5=bf64ccccdde77e617cc69ef07957aaeb
Notes: --- - "Export Date: 3 December 2012" - "CODEN: JSONA" - "Source: Scopus"
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MSK Authors
  1. Philip B Paty
    501 Paty
  2. Ronald P DeMatteo
    637 DeMatteo
  3. Andrea Cercek Hanjis
    356 Cercek Hanjis
  4. Peter Allen
    501 Allen
  5. William R Jarnagin
    911 Jarnagin
  6. Yuman Fong
    775 Fong
  7. John Brian Ammori
    9 Ammori
  8. Michael D'Angelica
    786 D'Angelica
  9. T Peter Kingham
    620 Kingham
  10. Nancy Kemeny
    545 Kemeny
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