A non-apoptotic role for Fas/FasL in erythropoiesis Journal Article
| Authors: | Carlile, G. W.; Smith, D. H.; Wiedmann, M. |
| Article Title: | A non-apoptotic role for Fas/FasL in erythropoiesis |
| Abstract: | Issues remain to be elucidated in the developmental regulation of erythropoiesis. In particular the role of Fas, a member of the tumor necrosis factor family of receptors despite much work remains unclear. During erythropoiesis, Fas is expressed at low levels on erythroblasts. For most cell types, Fas to FasL interaction causes apoptotic cell death via caspase activation. Here, we show that in humans, early erythroid progenitors are refractory to apoptosis triggered through Fas. Further during early human erythropoiesis, Fas triggered caspase activation provides a positive stimulus for erythroid maturation, and does not alter cellular proliferation or trigger apoptosis. © 2009 Federation of European Biochemical Societies. |
| Keywords: | controlled study; protein expression; human cell; protein function; cell proliferation; cell death; cells, cultured; apoptosis; cell maturation; erythroblast; erythropoiesis; erythroid precursor cells; protein protein interaction; fas antigen; fas ligand; rna, small interfering; caspase 3; enzyme activation; caspase; transfection; time factors; cysteine-aspartic acid protease; development; erythrocyte; fas; regulation; tumor necrosis factor receptor; caspase 8; caspase 9; erythroblasts; fas ligand protein |
| Journal Title: | FEBS Letters |
| Volume: | 583 |
| Issue: | 4 |
| ISSN: | 0014-5793 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2009-02-18 |
| Start Page: | 848 |
| End Page: | 854 |
| Language: | English |
| DOI: | 10.1016/j.febslet.2009.01.047 |
| PUBMED: | 19244619 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: FEBLA" - "Source: Scopus" |
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