Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses Journal Article
| Authors: | Moore, A.; Kane, E.; Teras, L. R.; Machiela, M. J.; Arias, J.; Panagiotou, O. A.; Monnereau, A.; Doo, N. W.; Wang, Z.; Slager, S. L.; Vermeulen, R. C. H.; Vajdic, C. M.; Smedby, K. E.; Spinelli, J. J.; Vijai, J.; Giles, G. G.; Link, B. K.; Arslan, A. A.; Nieters, A.; Bracci, P. M.; Camp, N. J.; Salles, G.; Cozen, W.; Hjalgrim, H.; De Vivo, I.; Adami, H.; Albanes, D.; Becker, N.; Benavente, Y.; Bisanzi, S.; Boffetta, P.; Brennan, P.; Brooks-Wilson, A. R.; Canzian, F.; Clavel, J.; Conde, L.; Cox, D. G.; Curtin, K.; Foretova, L.; Ghesquiè€res, H.; Glimelius, B.; Habermann, T. M.; Hofmann, J. N.; Lan, Q.; Liebow, M.; Lincoln, A.; Maynadie, M.; McKay, J.; Melbye, M.; Miligi, L.; Milne, R. L.; Molina, T. J.; Morton, L. M.; North, K. E.; Offit, K.; Padoan, M.; Piro, S.; Patel, A. V.; Purdue, M. P.; Ravichandran, V.; Riboli, E.; Severson, R. K.; Southey, M. C.; Staines, A.; Tinker, L. F.; Travis, R. C.; Wang, S. S.; Weiderpass, E.; Weinstein, S.; Zheng, T.; Chanock, S. J.; Rothman, N.; Birmann, B. M.; Cerhan, J. R.; Berndt, S. I. |
| Article Title: | Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses |
| Abstract: | <p>Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.</p> |
| Keywords: | obesity; risk; follicular lymphoma; genome-wide association; physical-activity; non-hodgkins-lymphoma; susceptibility loci; pooled analysis; cancer; anthropometric characteristics |
| Journal Title: | International Journal of Cancer |
| ISSN: | 0020-7136 |
| Publisher: | John Wiley & Sons |
| Publication status: | Online ahead of print |
| Date Published: | 2025-09-05 |
| Online Publication Date: | 2025-09-05 |
| Language: | English |
| ACCESSION: | WOS:001564404900001 |
| DOI: | 10.1002/ijc.70039 |
| PROVIDER: | wos |
| PUBMED: | 40910475 |
| Notes: | Article; Early Access -- MSK author Vijai Joseph's first and last names are reversed on the original publication -- Source: Wos |
