BRCA1/2 impact on the development of implant-associated lymphoma in women with breast cancer and textured implants Journal Article
| Authors: | Ghione, P.; Mandelker, D.; Arcila, M.; Seshan, V.; Terry, M. B.; Vijai, J.; Cordeiro, P.; Vanderbilt, C.; Pressley, J.; Chan, A.; Galasso, N.; Dogan, A.; Salles, G.; de Jong, D.; van Leeuwen, F.; Horwitz, S. |
| Article Title: | BRCA1/2 impact on the development of implant-associated lymphoma in women with breast cancer and textured implants |
| Abstract: | <p>Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a type of T-cell lymphoma arising near textured breast implants. In a Dutch population, a higher prevalence of BRCA1/2 was found in BIA-ALCL. We analyzed the risk of BIA-ALCL occurrence related to BRCA in a large population of women with implants followed after breast cancer (BC) mastectomy. We compared the prevalence of BRCA1/2 between women from a large cohort of patients with BC who did and did not develop BIA-ALCL after reconstruction with textured implants. Hazard ratios (HRs) of developing BIA-ALCL were estimated using Cox regression. We also conducted a case-control study. Of 520 patients with BC tested for BRCA, the age-adjusted rate of developing BIA-ALCL for women with BRCA was 16 times the rate of BIA-ALCL among women without BRCA (95% confidence interval [CI], 3.6-76.1; P < .0003). Carrying bilateral implants (HR, 3.9; 95% CI, 0.4-32.7), chemotherapy (HR, 0.95; 95% CI, 0.2-4.2), and radiotherapy (HR, 0.37; 95% CI, 0.04-3.1) were not associated with BIA-ALCL. We also conducted a case-control study with 13 BIA-ALCL patients matched 1:3 with 39 controls. We used a complete enumeration of Bernoulli probability to rule out a nonassociation of BRCA with BIA-ALCL (P = .0002). In this study, we defined the role of BRCA1/2 mutations as a risk factor in developing BIA-ALCL in patients with BC. These results will help women undergoing breast reconstruction or with textured implants in place.</p> |
| Keywords: | prevalence; risk; australia; mutations; large-cell lymphoma; carrier frequency; bia-alcl |
| Journal Title: | Blood Advances |
| Volume: | 9 |
| Issue: | 17 |
| ISSN: | 2473-9529 |
| Publisher: | American Society of Hematology |
| Date Published: | 2025-09-01 |
| Start Page: | 4436 |
| End Page: | 4443 |
| Language: | English |
| ACCESSION: | WOS:001567502500001 |
| DOI: | 10.1182/bloodadvances.2025016810 |
| PROVIDER: | wos |
| PMCID: | PMC12410559 |
| PUBMED: | 40512039 |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Paola Ghione -- Source: Wos |
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