Risk of breast implant-associated anaplastic large cell lymphoma in patients with textured tissue expanders Journal Article

   


Authors: Nelson, J. A.; McKernan, C. D.; Rubenstein, R. N.; Shamsunder, M. G.; Poulton, R.; Dabic, S.; Mehrara, B. J.; Disa, J. J.; Cordeiro, P. G.; McCarthy, C. M.
Article Title: Risk of breast implant-associated anaplastic large cell lymphoma in patients with textured tissue expanders
Abstract: Background: The association between textured implants and breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is well established, but the risk of BIA-ALCL in patients with transient exposure to a textured tissue expander (TE) is not as well documented. The aim of this study was to assess the incidence and risk of BIA-ALCL in patients with temporary exposure to a textured TE with subsequent smooth implant placement. Methods: This single-institution retrospective cohort study included all female patients who underwent two-stage breast reconstruction with placement of a textured TE from 1995 to 2016 with subsequent exchange to a smooth permanent implant. Primary outcome of interest was development of BIA-ALCL. Patients with exposure to textured implants were excluded. Follow-up was determined by last documented visit. The authors calculated summary statistics for exposure time and follow-up intervals. Results: Overall, 3310 patients had temporary exposure to a textured TE with exchange to a smooth implant, totaling 5201 textured TEs. Average textured TE exposure time was 6.7 months (median, 5.8 months). Average follow-up was 6.8 years (median, 6.3 years), ranging from 3.7 months to 18 years. No cases of BIA-ALCL were identified. Conclusions: As no cases of BIA-ALCL were identified, the risk of BIA-ALCL with short exposure to textured TEs is likely lower than the risk from exposure to permanent textured implants. Although longer follow-up is needed, these results can help counsel patients with previous exposure to textured TEs who are concerned about their risk of BIA-ALCL and can contribute to discussions on potential continued utility of textured TEs. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, IV. © 2023 Lippincott Williams and Wilkins. All rights reserved.
Keywords: retrospective studies; pathology; breast neoplasms; retrospective study; tissue expansion devices; breast tumor; breast endoprosthesis; breast implants; breast augmentation; tissue expander; breast implantation; lymphoma, large-cell, anaplastic; anaplastic large cell lymphoma; procedures; humans; human; female
Journal Title: Plastic and Reconstructive Surgery
Volume: 152
ISSN: 0032-1052
Publisher: Lippincott Williams & Wilkins  
Date Published: 2023-07-01
Start Page: 32
End Page: 37
Language: English
DOI: 10.1097/prs.0000000000010195
PROVIDER: scopus
PUBMED: 36728202
PMCID: PMC11687562
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164231525&doi=10.1097%2fPRS.0000000000010195&partnerID=40&md5=de30e2a4dcc87cc58b6f85bf9c9c1d01
Notes: Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding authors are Jonas Nelson and Colleen McCarthy -- Source: Scopus
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MSK Authors
  1. Joseph Disa
    263 Disa
  2. Babak Mehrara
    449 Mehrara
  3. Peter G Cordeiro
    283 Cordeiro
  4. Colleen Marie McCarthy
    144 McCarthy
  5. Jonas Allan Nelson
    210 Nelson
  6. Meghana G Shamsunder
    43 Shamsunder
  7. Stefan Dabic
    7 Dabic
  8. Cayla Mckernan
    8 Mckernan
  9. Robyn Rubenstein
    26 Rubenstein
  10. Richard Timothy Poulton
    4 Poulton
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