| Abstract: |
IntroductionLarge granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T-LGL.MethodsThe Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T-LGL diagnosed between 2000 and 2019, and patients with primary T-LGL were analyzed.ResultsPatients with primary T-LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T-LGL diagnosis.ConclusionPatients with primary T-LGL were found to have a higher incidence of SPMs. Further research is needed to better understand the reason for this increased risk.Trial RegistrationThe authors have confirmed clinical trial registration is not needed for this submission |
