Leveraging immunologically based therapies to treat diffuse large B-cell lymphoma Review
| Authors: | Lue, J. K.; Healton, S. E.; Salles, G. A. |
| Review Title: | Leveraging immunologically based therapies to treat diffuse large B-cell lymphoma |
| Abstract: | Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of aggressive lymphomas driven by distinct biological pathways. Although historically divided into two major subtypes on the basis of putative cell of origin, detailed genomic analyses have revealed additional classifications with prognostic implications. Additionally, the lymphoma microenvironment adds a layer of complexity distinct from genetic subclassifications and influences disease trajectory and response to therapies. Herein, we review the emerging roles of immune-based therapies to address this complex interplay between intrinsic genetic drivers and the surrounding tumor microenvironment in DLBCL. © 2025 Elsevier Inc. |
| Keywords: | controlled study; aged; review; t lymphocyte; drug combination; antibodies; drug therapy; therapy; diffuse large b-cell lymphoma; tumor microenvironment; diffuse large b cell lymphoma; cellular therapy; human; lymphoma tumor microenvironment; t-cell engagers |
| Journal Title: | Trends in Cancer |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Publication status: | Online ahead of print |
| Date Published: | 2025-07-23 |
| Online Publication Date: | 2025-07-23 |
| Language: | English |
| DOI: | 10.1016/j.trecan.2025.06.013 |
| PROVIDER: | scopus |
| PMCID: | PMC12326298 |
| PUBMED: | 40707282 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Gilles A. Salles -- Source: Scopus |
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