Identifying Links between Alzheimer’s Disease and Type 2 Diabetes through Proteomics Journal Article
| Authors: | Chen, T. N.; Orr, A. L.; Orr, A. G.; Vacanti, N. M. |
| Article Title: | Identifying Links between Alzheimer’s Disease and Type 2 Diabetes through Proteomics |
| Abstract: | Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both amyloidogenic, age-associated chronic diseases and their occurrences are linked by epidemiological evidence and common dysregulated molecular functions including glucose hypometabolism, dyslipidemias, and altered insulin signaling. High-throughput molecular profiling of the genome and transcriptome has advanced our understanding of their molecular links; however, proteomic signatures may reveal novel biomarkers and additional insights because proteins are the primary purveyors of molecular function. Herein, the contributions to our understanding of the molecular links between AD and T2D by high-throughput proteomics are reviewed. Collectively, the studies highlight strong, but broad, common molecular and metabolic signatures; however, more investigation is needed to define shared mechanisms and identify robust biomarkers and potential therapeutic targets. © 2025 American Chemical Society. |
| Keywords: | high-throughput; proteome; metabolism; insulin; interaction; diabetes; resistance; molecular; profiling; alzheimer’s |
| Journal Title: | Journal of Proteome Research |
| ISSN: | 1535-3893 |
| Publisher: | American Chemical Society |
| Publication status: | Online ahead of print |
| Date Published: | 2025-01-01 |
| Online Publication Date: | 2025-01-01 |
| Language: | English |
| DOI: | 10.1021/acs.jproteome.5c00404 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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