Cryoneurolysis: Parallel growth in PubMed publications and Google trends analysis reveals exponential interest Journal Article
| Authors: | Cornelis, F. H.; Bokhari, R.; Geevarghese, R.; Filippiadis, D. K. |
| Article Title: | Cryoneurolysis: Parallel growth in PubMed publications and Google trends analysis reveals exponential interest |
| Abstract: | Purpose: This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption. Materials and Methods: Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993–2025) using the keyword "cryoneurolysis." Statistical analyses included Mann–Kendall trend tests, Portmanteau white noise tests, Dickey–Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression. Results: Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3–4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver "Iovera" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8–50.4) in 2025 to 72.6 (95% CI: 59.2–86.0) by 2030. Conclusion: Analysis reveals parallel academic–public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030. © Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2025. |
| Keywords: | interventional radiology; peripheral nerves; pain management; google trends; cryoneurolysis |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 48 |
| Issue: | 8 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Publication status: | Published |
| Date Published: | 2025-08-01 |
| Online Publication Date: | 2025-01-01 |
| Start Page: | 1188 |
| End Page: | 1192 |
| Language: | English |
| DOI: | 10.1007/s00270-025-04118-3 |
| PROVIDER: | scopus |
| PUBMED: | 40640413 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Francois H. Cornelis -- Source: Scopus |
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