A wave of Thetis cells imparts tolerance to food antigens early in life Journal Article
| Authors: | Cabric, V.; Parisotto, Y. F.; Park, T.; Akagbosu, B.; Zhao, Z.; Lo, Y.; Shibu, G.; Fisher, L.; Paucar Iza, Y. A.; Leslie, C.; Brown, C. C. |
| Article Title: | A wave of Thetis cells imparts tolerance to food antigens early in life |
| Abstract: | In the intestine, peripherally induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of the antigen-presenting cells that instruct food-specific pTreg cells is poorly understood. We found that a subset of Thetis cells, TC IV, is required for food-specific pTreg cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes, suggesting that their presence underlies the phenomenon of oral tolerance. A wave of TC IV differentiation in the periweaning period was associated with a window of opportunity for enhanced pTreg cell generation in response to food antigens. Our findings indicate that TC IV may represent a therapeutic target for the treatment of food-associated allergic and inflammatory diseases. © 2025 American Association for the Advancement of Science. All rights reserved. |
| Keywords: | adult; controlled study; nonhuman; flow cytometry; ki 67 antigen; animal cell; mouse; cell infiltration; dendritic cell; animal experiment; inflammation; cell differentiation; food intake; regulatory t lymphocyte; immune response; antigen; immunotherapy; cd4+ t lymphocyte; tamoxifen; monocyte; intestine flora; macrophage; homeostasis; differentiation; tolerance; cell; histocompatibility; eosinophilia; lamina propria; ovalbumin; mesentery lymph node; food allergy; article; food antigen |
| Journal Title: | Science |
| Volume: | 389 |
| Issue: | 6757 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2025-07-17 |
| Start Page: | 268 |
| End Page: | 274 |
| Language: | English |
| DOI: | 10.1126/science.adp0535 |
| PUBMED: | 40373113 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Chrysothemis C. Brown -- Source: Scopus |
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