Responsible Artificial Intelligence governance in oncology Journal Article


Authors: Stetson, P. D.; Choy, J.; Summerville, N.; Baldwin-Medsker, A.; Mak, J.; Chatterjee, A.; Kim, K.; Kumar, C.; Samedy, P.; Halperin, J.; Voigt, L.; Jee, J.; Fraser, J.; Connor, M.; Harper, R.; Evard, R.; Offodile, A. C. 2nd
Article Title: Responsible Artificial Intelligence governance in oncology
Abstract: The use of Artificial Intelligence (AI) in healthcare is expanding rapidly, including in oncology. Although generic AI development and implementation frameworks exist in healthcare, no effective governance models have been reported in oncology. Our study reports on a Comprehensive Cancer Center’s Responsible AI governance model for clinical, operations, and research programs. We report our one-year AI Governance Committee results with respect to the registration and monitoring of 26 AI models (including large language models), 2 ambient AI pilots, and a review of 33 nomograms. Novel management tools for AI governance are shared, including an overall program model, model information sheet, risk assessment tool, and lifecycle management tool. Two AI model case studies illustrate lessons learned and our “Express Pass” methodology for select models. Open research questions are explored. To the best of our knowledge, this is one of the first published reports on Responsible AI governance at scale in oncology. © The Author(s) 2025.
Keywords: oncology; risk assessment; cancer center; artificial intelligence; diagnosis; clinical research; nomogram; life cycle; clinical operations; information management; human; article; research programs; intelligence models; language model; large language model; ambients; life cycle assessment; governance models; management tool; operations programs; program models; airplane pilot; responsible artificial intelligence
Journal Title: npj Digital Medicine
Volume: 8
ISSN: 2398-6352
Publisher: Nature Publishing Group  
Date Published: 2025-07-04
Start Page: 407
Language: English
DOI: 10.1038/s41746-025-01794-w
PROVIDER: scopus
PMCID: PMC12227680
PUBMED: 40615544
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Peter D. Stetson -- Source: Scopus
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