MRI for rectal cancer: Updates and controversies—AJR expert panel narrative review Review


Authors: Khasawneh, H.; Khatri, G.; Sheedy, S. P.; Nougaret, S.; Lambregts, D. M. J.; Santiago, I.; Kaur, H.; Smith, J. J.; Horvat, N.
Review Title: MRI for rectal cancer: Updates and controversies—AJR expert panel narrative review
Abstract: Rectal MRI is a critical tool in the care of patients with rectal cancer, having established roles for primary staging, restaging, and surveillance. The comprehensive diagnostic and prognostic information provided by MRI helps to optimize treatment decision-making. However, challenges persist in the standardization and interpretation of rectal MRI, particularly in the context of rapidly evolving treatment paradigms, including growing acceptance of nonoperative management. In this AJR Expert Panel Narrative Review, we address recent advances and key areas of contention related to the use of MRI for rectal cancer. Our objectives include discussing concepts regarding anatomic localization of rectal tumors; exploring the evolving rectal cancer treatment paradigm and implications for MRI assessment; reviewing updates and controversies regarding rectal MRI for locoregional staging, restaging, and surveillance; reviewing current rectal MRI acquisition protocols; and highlighting challenges in homogenizing and optimizing acquisition parameters. © American Roentgen Ray Society.
Keywords: review; treatment; cancer staging; nuclear magnetic resonance imaging; biological marker; radiotherapy; diagnosis; surgery; rectum cancer; rectum tumor; rectum; narrative; human; rectal mri; mri scanner; anatomic localization of rectal tumors; paradigm of rectal tumor; primary rectal tumor staging; restaging rectal mri
Journal Title: American Journal of Roentgenology
Volume: 224
Issue: 6
ISSN: 0361-803X
Publisher: American Roentgen Ray Society  
Date Published: 2025-06-01
Start Page: e2431523
Language: English
DOI: 10.2214/ajr.24.31523
PUBMED: 39320354
PROVIDER: scopus
PMCID: PMC12210418
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Source: Scopus
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  1. Jesse Joshua Smith
    227 Smith
  2. Natally Horvat
    104 Horvat