Gastric cancer Journal Article
| Authors: | Sundar, R.; Nakayama, I.; Markar, S. R.; Shitara, K.; van Laarhoven, H. W. M.; Janjigian, Y. Y.; Smyth, E. C. |
| Article Title: | Gastric cancer |
| Abstract: | Gastric cancer remains a major health challenge worldwide, with nearly 1 million new cases annually contributing to more than 650 000 deaths. Epidemiologically, gastric cancer shows substantial geographical variation in incidence, with higher rates in Asia, South America, and eastern Europe, and a rapid increase in early-onset cases among people younger than 50 years. Key risk factors for gastric cancer include Helicobacter pylori infection, diet, obesity, smoking, and genetic predisposition. Early detection through comprehensive diagnostic procedures is crucial for optimising treatment outcomes. Standard treatment approaches for locally advanced gastric cancer include surgical resection, particularly D2 lymphadenectomy, complemented by chemotherapy and radiotherapy. There is increasing implementation of minimally invasive surgical techniques for operable disease and integration of immune checkpoint inhibitors and targeted therapies for advanced stages. Emerging therapies, such as novel targeted treatments and next-generation immunotherapies, show promise in improving survival and quality of life. Future directions in the management of gastric cancer focus on precision medicine, continued advancement in immunotherapy, novel early detection methods, and a multidisciplinary approach to care. These strategies aim to enhance the overall effectiveness of treatment and prognosis worldwide. © 2025 Copyright © 2025 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies |
| Keywords: | adult; treatment outcome; review; nonhuman; lymph node dissection; quality of life; radiotherapy; incidence; risk factors; obesity; smoking; risk factor; immunotherapy; diagnosis; surgery; gastrectomy; stomach cancer; minimally invasive surgery; epidemiology; drug therapy; genetic predisposition; stomach neoplasms; early detection of cancer; therapy; helicobacter infections; stomach tumor; personalized medicine; etiology; complication; south america; helicobacter infection; data mining; immune checkpoint inhibitor; humans; human; male; early cancer diagnosis |
| Journal Title: | Lancet |
| Volume: | 405 |
| Issue: | 10494 |
| ISSN: | 0140-6736 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2025-01-01 |
| Start Page: | 2087 |
| End Page: | 2102 |
| Language: | English |
| DOI: | 10.1016/s0140-6736(25)00052-2 |
| PUBMED: | 40319897 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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