Synapse - Outcomes of reduced elective nodal radiation dose and volume for laryngeal, hypopharyngeal, and p16-negative oropharyngeal cancers

Outcomes of reduced elective nodal radiation dose and volume for laryngeal, hypopharyngeal, and p16-negative oropharyngeal cancers Journal Article

Authors:	Zakeri, K.; Wren, S. D.; Shang, T.; Yu, Y.; Chen, L.; Shamseddine, A.; Safavi, A. H.; Kang, J. J.; Tsai, C. J.; Sherman, E. J.; Wong, R. J.; McBride, S. M.; Gelblum, D.; Riaz, N.; Lee, N. Y.
Article Title:	Outcomes of reduced elective nodal radiation dose and volume for laryngeal, hypopharyngeal, and p16-negative oropharyngeal cancers
Abstract:	Background: Reducing elective nodal irradiation dose can decrease treatment toxicity and improve quality of life for head and neck cancer patients. Methods: We determined the effectiveness of reducing elective radiotherapy doses to 40 Gy for a consecutive cohort of laryngeal, hypopharyngeal, and p16-negative oropharyngeal or unknown primary squamous cell carcinomas treated with concurrent chemoradiation. The primary outcome measure was solitary elective nodal recurrence. Results: The cohort included 73 consecutive patients with a median follow up of 23.3 months. There were no cases of solitary elective nodal recurrence. Six patients had locoregional recurrence, eight had distant recurrence, and two had simultaneous locoregional and distant recurrence. All locoregional recurrences occured in the 70 Gy target volume (three in the primary tumor target, three in the involved node target, and two in both). Conclusions: Reduction in elective nodal radiation dose did not lead to solitary elective nodal recurrences for laryngeal, hypopharyngeal, and p16-negative oropharyngeal cancers. © 2025 Wiley Periodicals LLC.
Journal Title:	Head & Neck
ISSN:	1043-3074
Publisher:	John Wiley & Sons, Inc.
Publication status:	Online ahead of print
Date Published:	2025-06-14
Online Publication Date:	2025-06-14
Language:	English
DOI:	10.1002/hed.28217
PROVIDER:	scopus
PUBMED:	40515499
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-105008199733&doi=10.1002%2fhed.28217&partnerID=40&md5=2d74bd111ddfea5aa4b2d099df988fe6
Notes:	Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Nancy Lee -- Source: Scopus