Hepatic Arterial Infusion Chemotherapy for Intrahepatic Cholangiocarcinoma Book Section

  


Authors: Panni, R. Z.; Jarnagin, W. R.
Article/Chapter Title: Hepatic Arterial Infusion Chemotherapy for Intrahepatic Cholangiocarcinoma
Abstract: Intrahepatic cholangiocarcinoma (ICC) represents a formidable challenge due to its aggressive nature and frequent presentation with multifocal disease and intrahepatic metastasis. While surgical resection remains the cornerstone of treatment for localized disease, many patients are deemed unresectable at diagnosis. As systemic therapies such as chemotherapy, immunotherapy, and targeted agents advance, the role of liver-directed therapies, including hepatic arterial infusion (HAI) chemotherapy, has evolved significantly. The National Comprehensive Cancer Network (NCCN) now recommends HAI chemotherapy for patients with unresectable or metastatic ICC without extrahepatic spread. Several studies underscore the efficacy of combining HAI chemotherapy with systemic treatments over either modality alone in improving progression-free and overall survival rates. In this chapter we will review the current literature, emphasizing studies and ongoing trials that elucidate the evolving role of HAI chemotherapy in the management of unresectable ICC. By examining outcomes and exploring therapeutic strategies, this review aims to provide insights into optimizing treatment approaches for this challenging malignancy. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.
Keywords: systemic therapy; chemotherapy; liver; diagnosis; drug infusion; intrahepatic cholangiocarcinoma; cholangiocarcinoma; surgical resection; diseases; hepatic artery; multifocal; liver-directed therapy; hepatic artery infusion chemotherapy; localised; liver-directed therapies; arterial infusion chemotherapies
Book Title: Hepatic Arterial Infusion for Malignancy
ISBN: 978-303174935-3
Publisher: Springer Science + Business Media, LLC  
Date Published: 2025-01-01
Start Page: 191
End Page: 198
Language: English
DOI: 10.1007/978-3-031-74935-3_16
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-105008157923&doi=10.1007%2f978-3-031-74935-3_16&partnerID=40&md5=ef6f1a4cd28566514ff184a5b297d3a4
Notes: Book chapter -- Source: Scopus
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