Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone Journal Article


Authors: Konstantinidis, I. T.; Koerkamp, B. G.; Do, R. K. G.; Gönen, M.; Fong, Y.; Allen, P. J.; D'Angelica, M. I.; Kingham, T. P.; DeMatteo, R. P.; Klimstra, D. S.; Kemeny, N. E.; Jarnagin, W. R.
Article Title: Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone
Abstract: BACKGROUND Intrahepatic cholangiocarcinoma (ICC) is associated with poor survival. This study compared the outcomes of patients with unresectable ICC treated with hepatic arterial infusion (HAI) plus systemic chemotherapy (SYS) with the outcomes of patients treated with SYS alone. METHODS Consecutive patients with ICC were retrospectively reviewed. Clinicopathologic data were reviewed. Survival rates were compared by Kaplan-Meier analysis and log-rank testing. RESULTS Between January 2000 and August 2012, 525 patients with ICC were evaluated at Memorial Sloan Kettering Cancer Center, and 236 patients with unresectable tumors (locally advanced or metastatic) were analyzed. Disease was confined to the liver in 104 patients, who underwent treatment with combined HAI and SYS (n = 78 or 75%) or SYS alone (n = 26 or 25%). The response rate in the combined group was better than the rate in the group receiving SYS alone, although this did not reach statistical significance (59% vs 39%, P =.11). Overall survival for the combined group was longer than overall survival for the patients who received SYS alone (30.8 vs 18.4 months, P <.001), and this difference was maintained when patients with portal lymph node disease were included in the survival analysis (29.6 months with HAI and SYS [n = 93] vs 15.9 months with SYS [n = 74], P <.001). Eight patients who initially presented with unresectable tumors responded enough to undergo complete resection and had a median overall survival of 37 months (range, 10.4-92.3 months). CONCLUSIONS In patients with unresectable ICC confined to the liver or with limited regional nodal disease, a combination of SYS and HAI chemotherapy is associated with greater survival than SYS alone. © 2015 American Cancer Society.
Keywords: survival; intrahepatic cholangiocarcinoma; hepatic arterial infusion; systemic chemotherapy; floxuridine (fudr)
Journal Title: Cancer
Volume: 122
Issue: 5
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2016-03-01
Start Page: 758
End Page: 765
Language: English
DOI: 10.1002/cncr.29824
PROVIDER: scopus
PMCID: PMC4764409
PUBMED: 26695839
DOI/URL:
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
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MSK Authors
  1. Ronald P DeMatteo
    597 DeMatteo
  2. Mithat Gonen
    701 Gonen
  3. David S Klimstra
    843 Klimstra
  4. Peter Allen
    436 Allen
  5. William R Jarnagin
    583 Jarnagin
  6. Kinh Gian Do
    112 Do
  7. Yuman Fong
    741 Fong
  8. T Peter Kingham
    281 Kingham
  9. Nancy Kemeny
    346 Kemeny