Lung Carcinoma Book Section
| Authors: | Arcila, M. E.; Chang, J. C.; Tafe, L. J. |
| Article/Chapter Title: | Lung Carcinoma |
| Abstract: | Over the past decade, extensive research has led to the identification of several recurrent and mutually exclusive driver oncogene alterations underlying lung cancer pathogenesis. With further understanding of these genetic alterations as biomarkers and the advent of targeted therapies, molecular diagnostic testing of tumor samples has become an integral part of daily pathology practice. As such, the surgical pathologist has assumed a pivotal role in patient management, responsible for the delivery of accurate prognostic and predictive molecular genomic data in the context of tumor morphology. Working knowledge of the molecular biology of lung cancer and the basic technical aspects of testing are therefore important for all surgical pathologists to appropriately accomplish this role. In this chapter we provide a basic overview of established and emerging clinically relevant driver alterations in lung carcinoma, affecting key oncogenes including EGFR, KRAS, ALK, BRAF, HER2, PIK3CA, MEK1, MET, AKT, RET, ROS1, and NTRK1. © Springer Nature Switzerland AG 2020. |
| Keywords: | neurosurgery; lung cancer; proteomics; biopsy; lung carcinoma; biomolecules; biological organs; arthroplasty; genetic alterations; patient management; molecular diagnostics; cancer pathogenesis; diagnostic testing; transplantation (surgical); transplants; tumor samples; integral part; molecular genomics |
| Book Title: | Genomic Medicine: A Practical Guide |
| ISBN: | 978-303022922-1 |
| Publisher: | Springer |
| Date Published: | 2019-01-01 |
| Start Page: | 83 |
| End Page: | 101 |
| Language: | English |
| DOI: | 10.1007/978-3-030-22922-1_6 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter -- Source: Scopus |
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