US geriatric assessment practices for older adults undergoing hematopoietic cell transplantation or chimeric antigen receptor T cell therapy: An American Society for Transplantation and Cellular Therapy Physician survey from the Aging Special Interest Group and Committee on Practice Guidelines Guidelines

  

Authors:	Munshi, P. N.; Olin, R. L.; Wall, S.; McCurdy, S. R.; Al-Juhaishi, T.; Baker, J.; Bhatt, V. R.; Chokr, N.; Dahi, P.; DeFilipp, Z.; Espinoza-Gutarra, M.; Farhan, S.; Gowda, L.; Hamilton, B. K.; Inamoto, Y.; Jayani, R.; Kharfan-Dabaja, M. A.; Lin, R.; Meyers, G.; Mishra, A.; Murthy, H. S.; Nawas, M.; Rosko, A. E.; Ruiz, M.; Sorror, M. L.; Sung, A. D.; Carpenter, P. A.; Hamadani, M.; Artz, A. S.
Title:	US geriatric assessment practices for older adults undergoing hematopoietic cell transplantation or chimeric antigen receptor T cell therapy: An American Society for Transplantation and Cellular Therapy Physician survey from the Aging Special Interest Group and Committee on Practice Guidelines
Abstract:	Geriatric assessment (GA) may identify vulnerabilities and promote risk-stratification in older adults predisposed to toxicities after autologous (auto), allogeneic (allo) hematopoietic cell transplantation (HCT) and chimeric antigen T-cell therapies (CAR T). With increased utilization cellular therapies for older adults the American Society for Transplantation and Cellular Therapy (ASTCT) Committee on Practice Guidelines and its Special Interest Group for Aging (SIG) conducted an online cross-sectional survey between April 2023 and August 2023 to determine transplantation and cellular therapy physicians' practice patterns regarding GA in older patients receiving HCT and CAR T-cell therapies. E-mail surveys were sent to 1168 ASTCT physician members and only 96 (8.2%) respondents completed the survey. Most (86%) were affiliated with university/teaching centers and 70% had a combined HCT and cellular therapy practice. More than 50% of respondents were interested in pursuing GA but 68% described barriers. The top two recognized barriers to GA were lack of time (96%) and clinical support staff (90%). Despite interest, only 15% respondents reported to know the domains of GA ‘well’. Among those using GA, the minimum age used for routine GA was 65 years for allo-HCT and CAR T in over 91% respondents. Taken together, we recommend the HCT community leadership and GA experts combine efforts to address the gap in GA uptake and implementation. © 2025 The American Society for Transplantation and Cellular Therapy
Keywords:	adult; aged; middle aged; united states; clinical practice; health survey; practice guideline; hematopoietic stem cell transplantation; age; questionnaire; karnofsky performance status; physicians; societies, medical; practice guidelines as topic; medical society; cognition; physician; chimeric antigen receptor; cross-sectional study; cross-sectional studies; biological therapy; adoptive immunotherapy; immunotherapy, adoptive; geriatric assessment; descriptive research; nutrition; older patients; demographics; allogeneic; procedures; autologous; humans; human; male; female; article; physician survey; cell- and tissue-based therapy; surveys and questionnaires; practice patterns, physicians'; chimeric antigen receptor t-cell immunotherapy; chimeric antigen receptor t cell therapy; receptors, chimeric antigen
Journal Title:	Transplantation and Cellular Therapy
Volume:	31
Issue:	5
ISSN:	2666-6375
Publisher:	Elsevier Inc.
Date Published:	2025-05-01
Start Page:	285
End Page:	296
Language:	English
DOI:	10.1016/j.jtct.2025.02.014
PUBMED:	39961473
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000362752&doi=10.1016%2fj.jtct.2025.02.014&partnerID=40&md5=608863f3b6e9b8efb511a7f2cd8d9257
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/225707