Updated indications for immune effector cell therapy: 2023 guidelines from the American Society for Transplantation and Cellular Therapy Guidelines
| Authors: | Kanate, A. S.; Majhail, N.; DeFilipp, Z.; Dhakal, B.; Dholaria, B.; Hamilton, B.; Herrera, A. F.; Inamoto, Y.; Jain, T.; Perales, M. A.; Carpenter, P. A.; Hamadani, M. |
| Title: | Updated indications for immune effector cell therapy: 2023 guidelines from the American Society for Transplantation and Cellular Therapy |
| Abstract: | The American Society for Transplantation and Cellular Therapy (ASTCT) published its guidelines on indications for autologous and allogeneic hematopoietic cell transplantation (HCT) and immune effector cell therapy (IECT) in 2020. Since then, we have witnessed rapid advancements in the field of IECT, resulting in several new chimeric antigen receptor T cell (CAR-T) products and disease indications being approved by the US Food and Drug Administration (FDA). To keep abreast of these practice changes, the ASTCT Committee on Practice Guidelines commissioned a focused update covering CAR-T therapy indications. Here we present updated ASTCT recommendations on indications for CAR-T therapy. Only FDA-approved indications for CAR-T were recommended and categorized as “standard of care,” where the indication is well defined and supported by evidence. The ASTCT will continue to periodically review these guidelines and update them as new evidence becomes available. © 2023 The American Society for Transplantation and Cellular Therapy |
| Keywords: | multiple myeloma; practice guideline; food and drug administration; acute lymphoblastic leukemia; health care quality; medical society; allogeneic hematopoietic stem cell transplantation; cell therapy; effector cell; non-hodgkin lymphoma; indications; human; article; chimeric antigen receptor t cells; immune effector cell therapy |
| Journal Title: | Transplantation and Cellular Therapy |
| Volume: | 29 |
| Issue: | 10 |
| ISSN: | 2666-6375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-10-01 |
| Start Page: | 594 |
| End Page: | 597 |
| Language: | English |
| DOI: | 10.1016/j.jtct.2023.07.002 |
| PUBMED: | 37422194 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
