On-patient medical record and mRNA therapeutics using intradermal microneedles Journal Article
| Authors: | Han, J.; Kanelli, M.; Liu, Y.; Daristotle, J. L.; Pardeshi, A.; Forster, T. A.; Karchin, A.; Folk, B.; Murmann, L.; Tostanoski, L. H.; Carrasco, S. E.; Alsaiari, S. K.; Wang, E. Y.; Tran, K.; Zhang, L.; Eshaghi, B.; Levy, L.; Pyon, S.; Sloane, C.; Lin, S. Q.; Lau, A.; Perkinson, C. F.; Bawendi, M. G.; Barouch, D. H.; Durand, F.; Langer, R.; Jaklenec, A. |
| Article Title: | On-patient medical record and mRNA therapeutics using intradermal microneedles |
| Abstract: | Medical interventions often require timed series of doses, thus necessitating accurate medical record-keeping. In many global settings, these records are unreliable or unavailable at the point of care, leading to less effective treatments or disease prevention. Here we present an invisible-to-the-naked-eye on-patient medical record-keeping technology that accurately stores medical information in the patient skin as part of microneedles that are used for intradermal therapeutics. We optimize the microneedle design for both a reliable delivery of messenger RNA (mRNA) therapeutics and the near-infrared fluorescent microparticles that encode the on-patient medical record-keeping. Deep learning-based image processing enables encoding and decoding of the information with excellent temporal and spatial robustness. Long-term studies in a swine model demonstrate the safety, efficacy and reliability of this approach for the co-delivery of on-patient medical record-keeping and the mRNA vaccine encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This technology could help healthcare workers make informed decisions in circumstances where reliable record-keeping is unavailable, thus contributing to global healthcare equity. © The Author(s) 2025. |
| Keywords: | genetics; animal; animals; messenger rna; rna, messenger; medical record; injections, intradermal; disease control; point of care; needle; swine; vaccines; needles; pig; microinjections; prevention and control; microinjection; intradermal drug administration; naked-eye; coronavirus; disease prevention; microneedles; humans; human; electronic health record; records management; severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; covid-19; sars-cov-2; global settings; medical intervention; record keeping; rna therapeutics |
| Journal Title: | Nature Materials |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 1476-1122 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2025-05-01 |
| Start Page: | 794 |
| End Page: | 803 |
| Language: | English |
| DOI: | 10.1038/s41563-024-02115-4 |
| PUBMED: | 39994390 |
| PROVIDER: | scopus |
| PMCID: | PMC12048341 |
| DOI/URL: | |
| Notes: | Source: Scopus |
