Desmoplastic melanoma Review
| Author: | Busam, K. J. |
| Review Title: | Desmoplastic melanoma |
| Abstract: | Desmoplastic melanoma is a rare fibrosing variant of melanoma. It typically affects elderly patients but can occasionally affect young or middle-aged individuals. Desmoplastic melanoma is relevant as a diagnostic pitfall for pure tumor variants’ distinct histopathologic and clinical features. The latter includes a lower regional lymph node involvement frequency and a more favorable prognosis among thick melanomas. Classic cases of desmoplastic melanoma tend to carry a high mutation burden. Patients with metastases from those tumors tend to respond favorably to novel immunotherapies. © 2024 |
| Keywords: | immunohistochemistry; cancer surgery; gene mutation; clinical feature; histopathology; cancer radiotherapy; cancer diagnosis; cancer immunotherapy; differential diagnosis; immunoglobulin enhancer binding protein; protein p53; desmoplastic melanoma; immunophenotyping; melan a; monophenol monooxygenase; dermatofibroma; neurofibroma; molecular diagnosis; solar elastosis; pigmented nevus; connective tissue tumor; monoclonal antibody hmb 45; tp53 gene; nf1 gene; cancer prognosis; transcription factor sox10; human; article; neurothekeoma; tumor mutational burden; skin sarcoma; desmoplastic carcinoma; desmoplastic cellular neurothekeoma; mixed desmoplastic melanoma; nfkappab gene; pure desmoplastic melanoma; undifferentiated pleomorphic dermal sarcoma |
| Journal Title: | Clinics in Dermatology |
| Volume: | 43 |
| Issue: | 3 |
| ISSN: | 0738-081X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2025-04-30 |
| Start Page: | 341 |
| End Page: | 347 |
| Language: | English |
| DOI: | 10.1016/j.clindermatol.2024.09.005 |
| PUBMED: | 39260465 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- MSK corresponding author is Klaus Busam -- Source: Scopus |
