Gastrointestinal cancers Book Section
| Authors: | Reyngold, M.; Hajj, C.; Wu, A.; Romesser, P.; Crane, C. |
| Editors: | Cuaron, J. J.; Braunstein, L. Z. |
| Article/Chapter Title: | Gastrointestinal cancers |
| Abstract: | Gastrointestinal cancers comprise multiple malignancies with diverse etiologies arising from distinct subsites of the squamous and glandular epithelium of the gastrointestinal (GI) tract. Radiation therapy is an integral part of the established treatment paradigm for many of them. RT serves as the definitive modality for some (anal cancer) and as an adjuvant/neoadjuvant (esophageal and rectal cancer) or a primarily palliative for others. Moreover, the role for RT in the management of some GI malignancies is less established, either due to the relative rarity of the disease and paucity of data (cholangiocarcinoma), availability of multiple therapeutic alternatives (hepatocellular carcinoma), or changing data landscape regarding the efficacy of RT (pancreatic cancer). This chapter will systematically address the salient features of diagnosis and management of each sub-site, focusing on patient selection for RT and RT planning. Important emerging themes include organ preservation, which started with anal cancer, has now gained acceptance in rectal cancer and is being investigated for esophageal cancer, as well as dose escalation as a definitive treatment. Advanced technologies, including proton therapy, SBRT, and MRgRT, play an important role in a small number of clinical settings and will be specifically discussed where appropriate. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2025. |
| Keywords: | radiotherapy; liver metastasis; imrt; liver cancer; pancreatic cancer; diseases; esophageal cancer; sbrt; rectal cancer; gastric cancer; liver metastases; anal cancer; pancreatic cancers; proton beam therapy; liver cancers; mrgrt; gastric cancers |
| Book Title: | Radiation Oncology Clinical Fundamentals |
| ISBN: | 978-3-031-77558-1 |
| Publisher: | Springer Nature |
| Publication Place: | Cham, Switzerland |
| Date Published: | 2025-01-01 |
| Start Page: | 63 |
| End Page: | 82 |
| Language: | English |
| DOI: | 10.1007/978-3-031-77559-8_6 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter: 6 -- Source: Scopus |
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