Inguinal lymph node metastases from prostate cancer: Clinical, pathology, and multimodality imaging considerations Journal Article
| Authors: | Woo, S.; Becker, A. S.; Ghafoor, S.; Barbosa, F. G.; Arita, Y.; Vargas, H. A. |
| Article Title: | Inguinal lymph node metastases from prostate cancer: Clinical, pathology, and multimodality imaging considerations |
| Abstract: | Objective: To investigate clinical, pathology, and imaging findings associated with inguinal lymph node (LN) metastases in patients with prostate cancer (PCa). Materials and Methods: This was a retrospective single-center study of patients with PCa who underwent imaging and inguinal LN biopsy between 2000 and 2023. We assessed the following aspects on multimodality imaging: inguinal LN morphology; extrainguinal lymphadenopathy; the extent of primary and recurrent tumors; and non-nodal metastases. Imaging, clinical, and pathology features were compared between patients with and without metastatic inguinal LNs. Results: We evaluated 79 patients, of whom 38 (48.1%) had pathology-proven inguinal LN metastasis. Certain imaging aspects— short-axis diameter, prostate-specific membrane antigen uptake on positron-emission tomography, membranous urethra involvement by the tumor, extra-inguinal lymphadenopathy, and distant metastases—were associated with pathology-proven inguinal LN metastases (p < 0.01 for all). Associations with long-axis diameter, fatty hilum, laterality, and uptake of other tracers on positronemission tomography were not significant (p = 0.09–1.00). The patients with metastatic inguinal LNs had higher prostate-specific antigen levels and more commonly had castration-resistant PCa (p < 0.01), whereas age, histological grade, and treatment type were not significant factors (p = 0.07–0.37). None of the patients had inguinal LN metastasis in the absence of locally advanced disease with membranous urethra involvement or distant metastasis. Conclusion: Several imaging, clinical, and pathology features are associated with inguinal LN metastases in patients with PCa. Isolated metastasis to inguinal LNs is extremely rare and unlikely to occur in the absence of high-risk imaging, clinical, or pathology features. © 2024, Colegio Brasileiro de Radiologia. All rights reserved. |
| Keywords: | controlled study; human tissue; aged; major clinical study; histopathology; cancer recurrence; bone metastasis; nuclear magnetic resonance imaging; magnetic resonance imaging; lymph node metastasis; prostate specific antigen; pathology; diagnostic imaging; retrospective study; biopsy; histology; prostate cancer; imaging; tracer; inguinal lymph node; castration; lymph node biopsy; lymphadenopathy; lymph nodes/pathology; angioimmunoblastic t cell lymphoma; whole body mri; human; male; article; positron emission tomography-computed tomography; positron emission tomography computed tomography; prostatic neoplasms/diagnostic imaging; urethra/pathology |
| Journal Title: | Radiologia Brasileira |
| Volume: | 57 |
| ISSN: | 0100-3984 |
| Publisher: | Colegio Brasileiro de Radiologia * Departamento da Associacao Medica Brasileira |
| Date Published: | 2024-01-01 |
| Start Page: | e20240013 |
| Language: | English |
| DOI: | 10.1590/0100-3984.2024.0013 |
| PROVIDER: | scopus |
| PMCID: | PMC11235075 |
| PUBMED: | 38993954 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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40Becker -
20Arita
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