De-escalated management of HPV-positive oropharyngeal carcinoma: Improving outcomes with personalized approaches Review

  


Authors: Yacoub, I.; Shamseddine, A.; Qian, J.; Youssef, M.; Safavi, A. H.; Lee, N. Y.
Review Title: De-escalated management of HPV-positive oropharyngeal carcinoma: Improving outcomes with personalized approaches
Abstract: Human papilloma virus (HPV)-positive oropharyngeal cancer (OPC) is increasingly prevalent and has a favorable prognosis compared to HPV-negative OPC and other head and neck malignancies associated with smoking and alcohol. De-escalation of definitive therapy for HPV-positive OPC is an attractive strategy aiming to maintain oncologic efficacy while reducing short-term and long-term toxicities and improving quality of life. In this article, we outline approaches to de-escalation including use of alternative systemic therapies, reduction in dose of systemic therapy, and reductions in radiation dose and/or volume. We also highlight successes and cautionary outcomes from de-escalation studies and advocate for a personalized approach to future de-escalation trials in HPV-positive OPC. © 2025
Keywords: adult; controlled study; review; nonhuman; systemic therapy; radiation dose; quality of life; radiotherapy dosage; radiotherapy; smoking; virology; head and neck cancer; oropharynx cancer; drug therapy; therapy; oropharynx carcinoma; oropharyngeal neoplasms; wart virus; papillomavirus infections; personalized medicine; complication; oropharynx tumor; papillomavirus infection; procedures; papillomaviridae; humans; human; precision medicine
Journal Title: Seminars in Radiation Oncology
Volume: 35
Issue: 2
ISSN: 1053-4296
Publisher: Elsevier Inc.  
Date Published: 2025-04-01
Start Page: 157
End Page: 165
Language: English
DOI: 10.1016/j.semradonc.2025.01.004
PUBMED: 40090742
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-86000783603&doi=10.1016%2fj.semradonc.2025.01.004&partnerID=40&md5=64616200f73caa43f0af57ba5b3c7bc7
Notes: Review -- Source: Scopus
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MSK Authors
  1. Nancy Y. Lee
    870 Lee
  2. Achraf Shamseddine
    21 Shamseddine
  3. Irini Yacoub
    12 Yacoub
  4. Joshua Yuan Qian
    5 Qian
  5. Amir Safavi
    2 Safavi
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