Authors: | Haviv, D.; Nawy, T. |
Title: | Capturing and modeling cellular niches from dissociated single-cell and spatial data |
Abstract: | Cells interact with their local environment to enact global tissue function. By harnessing gene-gene covariation in cellular neighborhoods from spatial transcriptomics data, the covariance environment (COVET) niche representation and the environmental variational inference (ENVI) data integration method model phenotype-microenvironment interplay and reconstruct the spatial context of dissociated single-cell RNA sequencing datasets. |
Journal Title: | Nature Biotechnology |
Volume: | 43 |
Issue: | 2 |
ISSN: | 1087-0156 |
Publisher: | Nature Publishing Group |
Date Published: | 2025-02-01 |
Start Page: | 179 |
End Page: | 180 |
Language: | English |
ACCESSION: | WOS:001195788200003 |
DOI: | 10.1038/s41587-024-02207-1 |
PROVIDER: | wos |
PUBMED: | 38565975 |
Notes: | Source: Wos |