Synapse - CD4+ T-cell lymphoma harboring a chimeric antigen receptor integration in TP53

CD4+ T-cell lymphoma harboring a chimeric antigen receptor integration in TP53 Journal Article

Authors:	Perica, K.; Jain, N.; Scordo, M.; Patel, R.; Eren, O. C.; Patel, U.; Gundem, G.; Domenico, D.; Mitra, S.; Socci, N. D.; Everett, J. K.; Roche, A. M.; Petrichenko, A.; Shah, G. L.; Arcila, M. E.; Borsu, L.; Park, J. H.; Horwitz, S. M.; Giralt, S. A.; Dogan, A.; Leslie, C.; Papaemmanuil, E.; Bushman, F. D.; Usmani, S. Z.; Sadelain, M.; Mailankody, S.
Article Title:	CD4+ T-cell lymphoma harboring a chimeric antigen receptor integration in TP53
Abstract:	Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor suppressor, TP53, which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy. Copyright © 2025 Massachusetts Medical Society.
Keywords:	middle aged; genetics; case report; multiple myeloma; protein p53; t cell lymphoma; lymphoma, t-cell; immunology; cd4+ t lymphocyte; cd4-positive t-lymphocytes; lentivirus; tumor suppressor protein p53; chimeric antigen receptor; tp53 protein, human; therapy; adoptive immunotherapy; immunotherapy, adoptive; humans; human; male; b cell maturation antigen; b-cell maturation antigen; receptors, chimeric antigen
Journal Title:	New England Journal of Medicine
Volume:	392
Issue:	6
ISSN:	0028-4793
Publisher:	Massachusetts Medical Society
Date Published:	2025-02-06
Start Page:	577
End Page:	583
Language:	English
DOI:	10.1056/NEJMoa2411507
PUBMED:	39908432
PROVIDER:	scopus
PMCID:	PMC11801235
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85218290944&doi=10.1056%2fNEJMoa2411507&partnerID=40&md5=0d4fa9399da8399fba241ad4aaf57971
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Sham Mailankody -- Source: Scopus