BCMA-targeted CAR T-cell therapy plus radiotherapy for the treatment of refractory myeloma reveals potential synergy Journal Article
| Authors: | Smith, E. L.; Mailankody, S.; Staehr, M.; Wang, X.; Senechal, B.; Purdon, T. J.; Daniyan, A. F.; Geyer, M. B.; Goldberg, A. D.; Mead, E.; Santomasso, B. D.; Landa, J.; Rimner, A.; Riviere, I.; Landgren, O.; Brentjens, R. J. |
| Article Title: | BCMA-targeted CAR T-cell therapy plus radiotherapy for the treatment of refractory myeloma reveals potential synergy |
| Abstract: | We present a case of a patient with multiply relapsed, this response, which resembled cytokine-release syn-refractory myeloma whose clinical course showed evi-drome, immediately following XRT, we investigated dence of a synergistic abscopal-like response to chimeric changes in the patient's T-cell receptor (TCR) repertoire antigen receptor (CAR) T-cell therapy and localized radio-over 10 serial time points. Comparing T-cell diversity via therapy (XRT). Shortly after receiving B-cell maturation Morisita's overlap indices (CD), we discovered that, antigen (BCMA)–targeted CAR T-cell therapy, the patient although the diversity was initially stable after CAR T-cell required urgent high-dose steroids and XRT for spinal therapy compared with baseline (CD 1⁄4 0.89–0.97, base-cord compression. Despite the steroids, the patient had line vs. 4 time points after CAR T cells), T-cell diversity a durable systemic response that could not be attributed changed after the conclusion of XRT, with >30% newly to XRT alone. Post-XRT findings included a second wave expanded TCRs (CD 1⁄4 0.56–0.69, baseline vs. 4 time of fever and increased CRP and IL6, beginning 21 days points after XRT). These findings suggest potential synergy after CAR T cells, which is late for cytokine-release syn-between radiation and CAR T-cell therapies resulting in an drome from CAR T-cell therapy alone on this trial. Given abscopal-like response. © 2019 American Association for Cancer Research. |
| Journal Title: | Cancer Immunology Research |
| Volume: | 7 |
| Issue: | 7 |
| ISSN: | 2326-6066 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2019-07-01 |
| Start Page: | 1047 |
| End Page: | 1053 |
| Language: | English |
| DOI: | 10.1158/2326-6066.Cir-18-0551 |
| PUBMED: | 31113804 |
| PROVIDER: | scopus |
| PMCID: | PMC6606365 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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