Dosimetry software for theranostic applications: Current capabilities and future prospects Review


Authors: Kesner, A. L.; Brosch-Lenz, J.; Gear, J.; Lassmann, M.
Review Title: Dosimetry software for theranostic applications: Current capabilities and future prospects
Abstract: Dosimetry is integral to informed implementation of radiopharmaceutical therapies, enabling personalized treatment planning and ensuring patient safety by calculating absorbed doses to organs and tumors. As the therapeutic radiopharmaceutical field continues to expand, dosimetry software has emerged as a crucial tool for optimization of treatment efficacy. This review discusses key features and capabilities that current dosimetry software solutions have or should have in the future. We highlight the need for standardization across platforms to support consistent and accurate dose calculations. Furthermore, we explore opportunities for advancing software, such as incorporating biologically effective dose modeling and improving uncertainty quantification. Looking ahead, we advocate for expanding infrastructure for open data sets and fostering ongoing collaboration between vendors and end users to guide the field toward greater integration and efficacy. © 2025 by the Society of Nuclear Medicine andMolecular Imaging.
Keywords: review; treatment planning; radiotherapy; standardization; dosimetry; patient safety; radiopharmaceutical agent; nuclear medicine; radiometry; software; dose calculation; infrastructure; personalized medicine; humans; human; radiopharmaceutical therapies
Journal Title: Journal of Nuclear Medicine
Volume: 66
Issue: 2
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 2025-02-01
Start Page: 166
End Page: 172
Language: English
DOI: 10.2967/jnumed.124.268998
PUBMED: 39778969
PROVIDER: scopus
DOI/URL:
Notes: Review -- Source: Scopus
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  1. Adam Leon Kesner
    68 Kesner