The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer Review
| Authors: | Shafer, M.; Low, V.; Li, Z.; Blenis, J. |
| Review Title: | The emerging role of dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer |
| Abstract: | Propionate metabolism dysregulation has emerged as a source of metabolic health alterations linked to aging, cardiovascular and renal diseases, obesity and diabetes, and cancer. This is supported by several large cohort population studies and recent work revealing its role in cancer progression. Mutations in several enzymes of this metabolic pathway are associated with devastating inborn errors of metabolism, resulting in severe methylmalonic and propionic acidemias. Beyond these rare diseases, however, the broader pathological significance of propionate metabolism and its metabolites has been largely overlooked. Here, we summarize earlier studies and new evidence that the alteration of this pathway and associated metabolites are involved in the development of various metabolic diseases and link aging to cancer progression and metastasis. © 2025 Elsevier Inc. |
| Keywords: | review; cancer growth; neoplasm; neoplasms; animal; metabolism; animals; animal tissue; kidney disease; cohort analysis; obesity; pathology; diabetes mellitus; aging; metabolic disorder; metabolite; methylmalonic acid; inborn error of metabolism; metabolic diseases; metabolic disorders; tumor metabolism; branched chain amino acid; cancer metabolism; humans; human; malignant neoplasm; propionyl coenzyme a; propionates; propionic acid; propionate; propionic acidemia; bcaa metabolism; bcaas; branched-chain amino acids; methylmalonyl-coa; mma; propionyl-coa |
| Journal Title: | Cell Metabolism |
| Volume: | 37 |
| Issue: | 2 |
| ISSN: | 1550-4131 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2025-02-04 |
| Start Page: | 316 |
| End Page: | 329 |
| Language: | English |
| DOI: | 10.1016/j.cmet.2025.01.005 |
| PUBMED: | 39908986 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
