Late recurrence of completely resected stage I to IIIA lung adenocarcinoma Conference Paper
| Authors: | Fick, C. N.; Dunne, E. G.; Toumbacaris, N.; Tan, K. S.; Mastrogiacomo, B.; Park, B. J.; Adusumilli, P. S.; Molena, D.; Gray, K. D.; Sihag, S.; Huang, J.; Bott, M. J.; Rocco, G.; Isbell, J. M.; Jones, D. R. |
| Title: | Late recurrence of completely resected stage I to IIIA lung adenocarcinoma |
| Conference Title: | 104th Annual Meeting of the American Association for Thoracic Surgery (AATS) |
| Abstract: | Objective: Research into the risk factors associated with late recurrence (>2 years after surgery) of lung adenocarcinoma is limited. We investigated the incidence of and clinicopathologic and genomic features associated with late recurrence of resected stage I-IIIA lung adenocarcinoma. Methods: We performed a retrospective analysis of patients with completely resected pathologic stage I-IIIA lung adenocarcinoma (2010-2019). Patients with a history of lung cancer, neoadjuvant therapy, or mucinous or noninvasive lung adenocarcinoma, or with follow-up of less than 2 years were excluded. Cox and logistic regression modeling were used to compare clinicopathologic variables among patients with no, early (≤2 years), and late recurrence. Comparisons of genomic mutations were corrected for multiple testing. Results: Of the 2349 patients included, 537 developed a recurrence during follow-up. Most recurrences (55% [297/537]) occurred early; 45% (240/537) occurred late. A larger proportion of late recurrences than early recurrences were locoregional (37% vs 29%; P = .047). Patients with late recurrence had more aggressive pathologic features (International Association for the Study of Lung Cancer grade 2 and 3, lymphovascular invasion, visceral pleural invasion) and higher stage than patients without recurrence. Pathologic features were similar between patients with early and late recurrence, except stage IIIA disease was more common in the early cohort. No genomic mutations were associated with late recurrence. Conclusions: Late recurrence of lung adenocarcinoma after resection is more common than previously reported. Patients without disease more than 2 years after surgery who had aggressive pathologic features at the time of resection have an elevated risk of recurrence and may benefit from more aggressive follow-up. © 2024 The American Association for Thoracic Surgery |
| Keywords: | adult; controlled study; aged; middle aged; cancer surgery; retrospective studies; major clinical study; genetics; mutation; cancer recurrence; conference paper; neoadjuvant therapy; cancer staging; follow up; neoplasm staging; neoplasm recurrence, local; lung neoplasms; pneumonectomy; incidence; cohort analysis; risk factors; pathology; retrospective study; risk factor; time factors; risk assessment; lung tumor; lung adenocarcinoma; proportional hazards model; tumor recurrence; genomics; surgery; genetic risk; logistic regression analysis; lobectomy; pleura metastasis; adenocarcinoma of lung; time factor; wedge resection; clinicopathologic features; genomic mutation; lymph vessel metastasis; late recurrence; humans; human; male; female; segmentectomy |
| Journal Title | Journal of Thoracic and Cardiovascular Surgery |
| Volume: | 169 |
| Issue: | 2 |
| Conference Dates: | 2024 Apr 27-30 |
| Conference Location: | Toronto, Canada |
| ISBN: | 0022-5223 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2025-02-01 |
| Start Page: | 445 |
| End Page: | 453.e3 |
| Language: | English |
| DOI: | 10.1016/j.jtcvs.2024.06.026 |
| PROVIDER: | scopus |
| PMCID: | PMC11682191 |
| PUBMED: | 38950771 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: David R. Jones -- Source: Scopus |
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