Histologic subtyping in pathologic stage I-IIA lung adenocarcinoma provides risk-based stratification for surveillance Journal Article
| Authors: | Takahashi, Y.; Eguchi, T.; Kameda, K.; Lu, S.; Vaghjiani, R. G.; Tan, K. S.; Travis, W. D.; Jones, D. R.; Adusumilli, P. S. |
| Article Title: | Histologic subtyping in pathologic stage I-IIA lung adenocarcinoma provides risk-based stratification for surveillance |
| Abstract: | Background: We hypothesize that recurrence hazard following resection for stage I-IIA lung adenocarcinoma (ADC) varies according to histologic subtype, which may provide risk stratification for surveillance better than the current uniform follow-up protocol. Results: Presence (≥5%) of high-grade histologic subtypes (MIP and/or SOL) was associated with a significantly higher recurrence hazard: (1) presence of either MIP or SOL was associated with a significant increase in recurrence hazard during the first two years after surgery; (2) presence of SOL was associated with an increase in recurrence hazard-in particular, distant recurrence hazard-during the first year after surgery; (3) absence of high-grade subtypes (515/1,572 patients) was associated with a very low recurrence hazard (<2% risk/year) during the first ten years after surgery. Methods: All hematoxylin and eosin-stained tumor slides from pathologic stage I-IIA lung ADC (n = 1572) were reviewed for quantification of the percentage of each histological subtype. Recurrence hazard was estimated using the Kernel-Epanechnikov smoothing procedure. The association between recurrence hazard and high-grade histologic subtypes (micropapillary [MIP] and solid [SOL]) was assessed. Conclusions: Our findings suggest that histologic subtyping has utility for identifying recurrence hazard for surgically resected stage I-IIA lung ADC patients and provide rationale for establishing risk-based surveillance. © Copyright: Takahashi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 |
| Keywords: | dynamics; micropapillary; solid; prognosis; recurrence hazard |
| Journal Title: | Oncotarget |
| Volume: | 9 |
| Issue: | 87 |
| ISSN: | 1949-2553 |
| Publisher: | Impact Journals |
| Date Published: | 2018-11-06 |
| Start Page: | 35742 |
| End Page: | 35751 |
| Language: | English |
| PROVIDER: | scopus |
| DOI: | 10.18632/oncotarget.26285 |
| PMCID: | PMC6254662 |
| PUBMED: | 30515266 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 December 2018 -- Source: Scopus |
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