Financial challenges of being on long-term, high-cost medications Review
| Authors: | Elshiekh, C.; Rudà, R.; Scheffer Cliff, E. R.; Gany, F.; Budhu, J. A. |
| Review Title: | Financial challenges of being on long-term, high-cost medications |
| Abstract: | The isocitrate dehydrogenase (IDH) inhibitor, vorasidenib, may offer a promising new treatment option for patients with IDH-mutant gliomas. However, the indefinite nature of this targeted therapy raises significant financial concerns. High costs of targeted cancer therapies, often exceeding $150 000 annually, contribute to financial toxicity, characterized by medical debt, income loss, and psychological stress, and place stress on health systems. This review analyzes the drug approval and pricing mechanisms in various countries and their impact on healthcare costs and patient access, focusing specifically on the impacts in neuro-oncology. The United States employs a market-driven approach resulting in higher drug prices, while most countries, such as the United Kingdom, Germany, France, Italy, Japan, South Africa, and Brazil, use negotiated pricing and health technology assessment to manage costs. The financial burden of expensive medications affects patient adherence and quality of life, with many cancer patients facing substantial out-of-pocket expenses and potential treatment abandonment, and many more unable to access these drugs altogether. Vorasidenib's introduction, while potentially improving patient outcomes, may exacerbate financial toxicity unless mitigated by patient access programs and cost-management strategies. As neuro-oncology treatment paradigms evolve, understanding the economic implications of new therapies is essential to ensure equitable access and optimize patient care. © 2024 The Author(s). |
| Keywords: | overall survival; bevacizumab; temozolomide; quality of life; vincristine; lomustine; procarbazine; irinotecan; drug cost; health care cost; health care utilization; medicare; patient care; patient compliance; health care system; postmarketing surveillance; fluoxetine; cost-effectiveness analysis; drug interaction; infliximab; pyrazinamide; physiological stress; human; article; social determinants of health; osimertinib; financial toxicity; drug pricing; health equity; ivosidenib; financial stress; public health insurance |
| Journal Title: | Neuro-Oncology Practice |
| Volume: | 12 |
| Issue: | Suppl. 1 |
| ISSN: | 2054-2577 |
| Publisher: | Oxford University Press |
| Date Published: | 2025-02-01 |
| Start Page: | i49 |
| End Page: | i58 |
| Language: | English |
| DOI: | 10.1093/nop/npae098 |
| PROVIDER: | scopus |
| PMCID: | PMC11703369 |
| PUBMED: | 39776525 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- MSK corresponding author is Joshua Budhu -- Source: Scopus |
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