Molecular basis of breast tumor heterogeneity Journal Article

  


Authors: Dikoglu, E.; Pareja, F.
Article Title: Molecular basis of breast tumor heterogeneity
Abstract: Breast cancer (BC) is a profoundly heterogenous disease, with diverse molecular, histological, and clinical variations. The intricate molecular landscape of BC is evident even at early stages, illustrated by the complexity of the evolution from precursor lesions to invasive carcinoma. The key for therapeutic decision-making is the dynamic assessment of BC receptor status and clinical subtyping. Hereditary BC adds an additional layer of complexity to the disease, given that different cancer susceptibility genes contribute to distinct phenotypes and genomic features. Furthermore, the various BC subtypes display distinct metabolic demands and immune microenvironments. Finally, genotypic-phenotypic correlations in special histologic subtypes of BC inform diagnostic and therapeutic approaches, highlighting the significance of thoroughly comprehending BC heterogeneity. © 2025. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Keywords: genetics; phenotype; metabolism; genetic predisposition to disease; breast cancer; pathology; breast neoplasms; tumor marker; breast tumor; genetic predisposition; genetic heterogeneity; tumor microenvironment; intratumor heterogeneity; humans; human; female; breast cancer subtypes; tumor evolution; biomarkers, tumor
Journal Title: Advances in Experimental Medicine and Biology
Volume: 1464
ISSN: 0065-2598
Publisher: Springer  
Date Published: 2025-01-01
Start Page: 237
End Page: 257
Language: English
DOI: 10.1007/978-3-031-70875-6_13
PUBMED: 39821029
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85216043743&doi=10.1007%2f978-3-031-70875-6_13&partnerID=40&md5=45da14405231fc422151ba75cb5eaa70
Notes: Chapter 13 in "A Guide to Breast Cancer Research: From Cellular Heterogeneity and Molecular Mechanisms to Therapy" (ISBN: 978-3-031-70874-9) -- Source: Scopus
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MSK Authors
  1. Fresia Gilda Pareja Zea
    216 Pareja Zea
  2. Esra Dikoglu
    5 Dikoglu
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