Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes Review
| Authors: | Pareja, F.; Bhargava, R.; Borges, V. F.; Brogi, E.; Canas Marques, R.; Cardoso, F.; Desmedt, C.; Harigopal, M.; Lakhani, S. R.; Lee, A.; Leone, J. P.; Linden, H.; Lord, C. J.; Marchio, C.; Merajver, S. D.; Rakha, E.; Reis-Filho, J. S.; Richardson, A.; Sawyer, E.; Schedin, P.; Schwartz, C. J.; Tutt, A.; Ueno, N. T.; Vincent-Salomon, A.; Weigelt, B.; Wen, Y. H.; Schnitt, S. J.; Oesterreich, S. |
| Review Title: | Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes |
| Abstract: | Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases. Uncommon BC presentations like male, inflammatory and pregnancy-related BC pose challenges. Emerging therapeutic strategies targeting genetic alterations or immune microenvironment are being explored. © The Author(s) 2025. |
| Keywords: | adult; review; phenotype; breast cancer; inflammation; histology; artificial intelligence; diagnosis; genetic predisposition; human; male; female |
| Journal Title: | npj Breast Cancer |
| Volume: | 11 |
| ISSN: | 2374-4677 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2025-01-24 |
| Start Page: | 6 |
| Language: | English |
| DOI: | 10.1038/s41523-025-00719-w |
| PROVIDER: | scopus |
| PMCID: | PMC11760369 |
| PUBMED: | 39856067 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Fresia Pareja -- Source: Scopus |
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