Stereotactic body radiation therapy for primary renal cell carcinoma: A case-based radiosurgery society practice guide Journal Article
| Authors: | Barbour, A. B.; Upadhyay, R.; Anderson, A. C.; Kutuk, T.; Kumar, R.; Wang, S. J.; Psutka, S. P.; Fekrmandi, F.; Skalina, K. A.; Bruynzeel, A. M. E.; Correa, R. J. M.; Dal Pra, A.; Biancia, C. D.; Hannan, R.; Louie, A.; Singh, A. K.; Swaminath, A.; Tang, C.; Teh, B. S.; Zaorsky, N. G.; Lo, S. S.; Siva, S. |
| Article Title: | Stereotactic body radiation therapy for primary renal cell carcinoma: A case-based radiosurgery society practice guide |
| Abstract: | Traditionally, renal cell carcinoma (RCC) was considered a radioresistant tumor, thereby limiting definitive radiation therapy management options. However, several recent studies have demonstrated that stereotactic body radiation therapy (SBRT) can achieve high rates of local control for the treatment of primary RCC. In the setting of expanding use of SBRT for primary RCC, it is crucial to provide guidance on practical considerations such as patient selection, fractionation, target delineation, and response assessment. This is particularly important in challenging scenarios where a paucity of evidence exists, such as in patients with a solitary kidney, bulky tumors, or tumor thrombus. The Radiosurgery Society endorses this case-based guide to provide a practical framework for delivering SBRT to primary RCC, exemplified by 3 cases. This article explores topics of tumor size and dose fractionation, impact on renal function and treatment in the setting of a solitary kidney, and radiation's role in the management of inferior vena cava tumor thrombus. Additionally, we review existing evidence and expert opinion on target delineation, advanced techniques such as magnetic resonance imaging guided SBRT, and SBRT response assessment. © 2024 American Society for Radiation Oncology |
| Keywords: | clinical article; human tissue; aged; case report; cancer staging; nuclear magnetic resonance imaging; follow up; computer assisted tomography; tumor volume; nausea; vomiting; renal cell carcinoma; radiation response; lung embolism; partial nephrectomy; radical nephrectomy; kidney function; radiation dose fractionation; comorbidity; weakness; stereotactic body radiation therapy; atrial fibrillation; coronary artery disease; brain hemorrhage; kidney biopsy; solitary kidney; clear cell renal cell carcinoma; tumor thrombus; thrombectomy; human; female; article; diastolic heart failure; inferior vena cava tumor thrombus |
| Journal Title: | Practical Radiation Oncology |
| Volume: | 15 |
| Issue: | 1 |
| ISSN: | 1879-8519 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2025-01-01 |
| Start Page: | 74 |
| End Page: | 85 |
| Language: | English |
| DOI: | 10.1016/j.prro.2024.06.012 |
| PUBMED: | 39019209 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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