Outcomes of definitive radiotherapy vs. laryngectomy followed by adjuvant radiotherapy in patients with locally advanced laryngeal squamous cell carcinoma: Real-world experience in a referral cancer center Journal Article
| Authors: | Kazemian, A.; Esmati, E.; Ghalehtaki, R.; Farazmand, B.; Mousavi-Darzikolaee, N.; Bayani, R.; Razmkhah, M.; Taherioun, M.; Saeedi, N.; Heidari, F.; Zakeri, K. |
| Article Title: | Outcomes of definitive radiotherapy vs. laryngectomy followed by adjuvant radiotherapy in patients with locally advanced laryngeal squamous cell carcinoma: Real-world experience in a referral cancer center |
| Abstract: | Background: Laryngeal cancer is a common head and neck cancer. Surgical treatment can impair patients’ voice and swallowing function, making definitive radiotherapy a viable alternative for locally advanced cases. Methods: To compare the outcomes of definitive versus adjuvant radiotherapy in patients with primary locally advanced laryngeal cancer, we retrospectively evaluated consecutive patients treated from 2007 to 2020. We assessed and compared the median and 3-year overall survival (OS), disease-free survival (DFS), distant metastasis control (DMC), and local recurrence-free survival (LRC) in all patients and in T4 patients exclusively. Results: One hundred patients were studied, including definitive (N = 64) and adjuvant (N = 36) radiotherapy. The median follow-up was 29 months. Overall, the median OS in the definitive vs. adjuvant group was 100 months (95%CI = 46.5-153.5) vs. not reached, respectively (log-rank P = 0.506). The median DFS in the definitive vs. adjuvant group was 20 months (95%CI = 7.7–32.3) vs. not reached, respectively (log-rank P = 0.148). Three-year OS and DFS rates in all patients were 64% (95%CI: 48–78) vs. 75% (95%CI: 55–95) and 43% (95%CI:29–57) vs. 61% (95%CI: 41–81) in the definitive vs. adjuvant groups, respectively. Among T4 patients, the median OS in the definitive RT group vs. adjuvant group was not reached vs. 48 (95%CI = 0-105.3), respectively (log-rank P = 0.788). The median DFS in the definitive RT group vs. adjuvant group was 12 months (95%CI = 9.34–14.65) vs. 36 months (95%CI = 4.4–67.5), respectively (log-rank P = 0.868). Three-year OS and DFS rates were 71% (95%CI: 42–100) vs. 75% (95%CI: 50–100) and 40% (95%CI:21–79) vs. 56% (95%CI: 25–87) in the definitive vs. adjuvant groups, respectively. Conclusions: Our analysis suggests that definitive radiotherapy in laryngeal cancer does not lead to a poorer outcome than total laryngectomy followed by adjuvant radiotherapy. In T4 patients, our findings should reassure clinicians and patients about the viability of definitive radiotherapy as a treatment approach. © The Author(s) 2024. |
| Keywords: | adult; treatment outcome; aged; aged, 80 and over; middle aged; survival rate; retrospective studies; major clinical study; overall survival; fatigue; mortality; neutropenia; laryngectomy; laryngeal neoplasms; cisplatin; fluorouracil; treatment planning; comparative study; disease free survival; radiotherapy, adjuvant; cancer staging; nuclear magnetic resonance imaging; follow up; computer assisted tomography; multiple cycle treatment; nephrotoxicity; anemia; leukopenia; mucosa inflammation; neuropathy; thrombocytopenia; radiotherapy; cohort analysis; pathology; retrospective study; cetuximab; docetaxel; hypomagnesemia; dysphagia; odynophagia; cancer center; radiation dose fractionation; acne; patient compliance; nausea and vomiting; surgery; intermethod comparison; dermatitis; drug therapy; adjuvant radiotherapy; granulocyte colony stimulating factor; induction chemotherapy; laryngoscopy; hypocalcemia; ototoxicity; recurrence free survival; gross tumor volume; clinical target volume; head and neck squamous cell carcinoma; conformal radiotherapy; larynx tumor; pharyngitis; definitive radiotherapy; maintenance chemotherapy; consolidation chemotherapy; distant metastasis free survival; very elderly; humans; human; male; female; article; larynx squamous cell carcinoma; squamous cell carcinoma of head and neck; laryngeal neoplasms, head and neck neoplasms |
| Journal Title: | Radiation Oncology |
| Volume: | 19 |
| ISSN: | 1748-717X |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2024-12-18 |
| Start Page: | 180 |
| Language: | English |
| DOI: | 10.1186/s13014-024-02565-9 |
| PUBMED: | 39696417 |
| PROVIDER: | scopus |
| PMCID: | PMC11656933 |
| DOI/URL: | |
| Notes: | Source: Scopus |
