Hypopharyngeal squamous cell carcinoma: Three-dimensional or intensity-modulated radiotherapy? A single institution's experience Journal Article
| Authors: | Katsoulakis, E.; Riaz, N.; Hu, M.; Morris, L.; Sherman, E.; McBride, S.; Lee, N. |
| Article Title: | Hypopharyngeal squamous cell carcinoma: Three-dimensional or intensity-modulated radiotherapy? A single institution's experience |
| Abstract: | Objectives/Hypothesis Compare outcomes of hypopharyngeal carcinoma that received conventional radiotherapy versus intensity-modulated radiotherapy (IMRT). Study Design Retrospective single-institution trial. Methods Between April 1990 and May 2011, 100 patients with hypopharyngeal cancer underwent curative radiotherapy (RT) at our institution: 50 with IMRT and 50 with conventional RT. The median age was 63 years. There were 12 T1, 22 T2, 37 T3, and 28 T4 patients. The majority of patients (82%) had nodal disease: 54% N2 and 8% N3. The majority of patients (83%) received chemotherapy. Of the patients who received chemotherapy, 84% received a platinum-based regimen. The median RT dose was 7,000 cGy. The majority of patients (62%) had prophylactic percutaneous endoscopic gastrostomy tube placement. Toxicities were reviewed. Local control (LC), locoregional control (LRC), freedom from distant metastasis (FFM) rates, functional larynx preservation (LP), laryngectomy-free survival (LFS), and overall-survival (OS) curves were generated using the Kaplan-Meier method. The log-rank test was used to test prognostic variables. Results With a median follow up of 48.4 months, the 3/5-year LC, LRC, FFM, LP, LFS and OS rates were 74%/69%, 77%/74%, 70%/66%, 51%/29%, 49.6%/31.8%, and 49%/34%, respectively. The median OS was 2.9 years. The 3-year LC rate for IMRT was 77% versus 81% for conventional RT (P =.91); 3-year LRC for IMRT was 85% versus 76% for conventional RT (P =.32). There was no increased local failure with IMRT. There was no difference in the rate of stricture with IMRT (32%) versus conventional RT (25.3%) (P =.86). Conclusions IMRT achieved comparable LC and LRC rates to conventional RT. Level of Evidence 4 Laryngoscope, 126:620-626, 2016 © 2015 The American Laryngological, Rhinological and Otological Society, Inc. |
| Keywords: | intensity-modulated radiotherapy; organ preservation; hypopharyngeal carcinoma |
| Journal Title: | Laryngoscope |
| Volume: | 126 |
| Issue: | 3 |
| ISSN: | 0023-852X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2016-03-01 |
| Start Page: | 620 |
| End Page: | 626 |
| Language: | English |
| DOI: | 10.1002/lary.25509 |
| PROVIDER: | scopus |
| PUBMED: | 26597398 |
| PMCID: | PMC4940128 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 March 2016 -- Source: Scopus |
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